ID   CYRI_DICDI              Reviewed;         315 AA.
AC   Q8T2H0; Q55A05;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=CYFIP-related Rac1 interactor homolog {ECO:0000305};
GN   Name=cyri; Synonyms=fam49; ORFNames=DDB_G0272190;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May negatively regulate RAC1 signaling and RAC1-driven
CC       cytoskeletal remodeling. {ECO:0000250|UniProtKB:Q9H0Q0}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-
CC       anchor {ECO:0000250|UniProtKB:Q9NUQ9}.
CC   -!- SIMILARITY: Belongs to the CYRI family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71247.1; -; Genomic_DNA.
DR   RefSeq; XP_645179.1; XM_640087.1.
DR   AlphaFoldDB; Q8T2H0; -.
DR   SMR; Q8T2H0; -.
DR   STRING; 44689.DDB0233320; -.
DR   PaxDb; Q8T2H0; -.
DR   EnsemblProtists; EAL71247; EAL71247; DDB_G0272190.
DR   GeneID; 8618351; -.
DR   KEGG; ddi:DDB_G0272190; -.
DR   dictyBase; DDB_G0272190; fam49.
DR   eggNOG; KOG3951; Eukaryota.
DR   HOGENOM; CLU_056470_0_0_1; -.
DR   InParanoid; Q8T2H0; -.
DR   OMA; DAVKMCT; -.
DR   PhylomeDB; Q8T2H0; -.
DR   Reactome; R-DDI-114608; Platelet degranulation.
DR   PRO; PR:Q8T2H0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR039789; CYRI.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   PANTHER; PTHR12422; PTHR12422; 1.
DR   Pfam; PF07159; DUF1394; 1.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Reference proteome.
FT   CHAIN           1..315
FT                   /note="CYFIP-related Rac1 interactor homolog"
FT                   /id="PRO_0000327397"
SQ   SEQUENCE   315 AA;  35574 MW;  839D1B89509E527B CRC64;
     MGQLLSFING NDHTEQIFID FEHAQPSDDE RELHKTVNEV LIRGPAIIDK LLAYAGCNEF
     IRRAITNPGP ETEDAAWEAV LPSVDQLQEF YDFSLELETC FPKLLVALCK NDPKASLSNQ
     QALAKQLADI FDFVLKFDDA KMVNPAIQND FSYYRRTLNR MKLTKKDANI KIRDELANRM
     SLFFAYPTPM MKVLSETTVK FLSQDTTVPR DNVTTALATM ANVCHDMVEK KKFTQDDLNM
     FCLRAMVGSI ILFDHIHPQG AFVKKSPVNI KPCIVTLKDS NTQSSPGLLN ALRFTTIHLN
     DVDTPGAIKQ LLLLD