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CYS14_NEUCR
ID   CYS14_NEUCR             Reviewed;         819 AA.
AC   P23622; Q7RZ41;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 3.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Sulfate permease 2;
DE   AltName: Full=Sulfate permease II;
GN   Name=cys-14; ORFNames=G21B4.280, NCU04433;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1825178; DOI=10.1021/bi00221a008;
RA   Ketter J.S., Jarai G., Fu Y.-H., Marzluf G.A.;
RT   "Nucleotide sequence, messenger RNA stability, and DNA recognition elements
RT   of cys-14, the structural gene for sulfate permease II in Neurospora
RT   crassa.";
RL   Biochemistry 30:1780-1787(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [4]
RP   IDENTIFICATION OF SEQUENCE ERRORS IN SEQUENCE DESCRIBED IN PUBMED:1825178.
RX   PubMed=8140616; DOI=10.1016/0968-0004(94)90168-6;
RA   Sandal N.N., Marcker K.A.;
RT   "Similarities between a soybean nodulin, Neurospora crassa sulphate
RT   permease II and a putative human tumour suppressor.";
RL   Trends Biochem. Sci. 19:19-19(1994).
CC   -!- FUNCTION: Uptake of sulfate into the cell.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Mainly found in mycelia.
CC   -!- INDUCTION: Highly expressed, but only in cells subject to sulfur
CC       limitation, and it is turned on by the positive-acting 'Cys-3' sulfur
CC       regulatory protein.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA33615.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M59167; AAA33615.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BX908808; CAF06013.1; -; Genomic_DNA.
DR   EMBL; CM002239; EAA28274.3; -; Genomic_DNA.
DR   PIR; A37956; A37956.
DR   RefSeq; XP_957510.3; XM_952417.3.
DR   AlphaFoldDB; P23622; -.
DR   SMR; P23622; -.
DR   STRING; 367110.P23622; -.
DR   TCDB; 2.A.53.1.2; the sulfate permease (sulp) family.
DR   EnsemblFungi; EAA28274; EAA28274; NCU04433.
DR   GeneID; 3873616; -.
DR   KEGG; ncr:NCU04433; -.
DR   VEuPathDB; FungiDB:NCU04433; -.
DR   HOGENOM; CLU_003182_8_1_1; -.
DR   InParanoid; P23622; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   PANTHER; PTHR11814; PTHR11814; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00815; sulP; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..819
FT                   /note="Sulfate permease 2"
FT                   /id="PRO_0000080183"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          551..708
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT   REGION          726..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        581
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   819 AA;  89321 MW;  965509C1802ECC1A CRC64;
     MASTSTAGDR IKKFLGIPAD ERLNDTACYV DGSFVESEPT TQDFLNEIRP TVQGTLNYLR
     ELFPFVNWIF HYNLTWLLGD FIAGVTVGFV VVPQGMAYAK LANLAPEYGL YTSFVGFVLY
     WAFATSKDIT IGAVAVMSTI VGNIIANVQK DHPDFDAGDI ARTLAFISGA MLLFLGLIRF
     GFIVEFIPIV AISAFMTGSA ISIAAGQVST LMGIPNINSR EETYKVIINT LKGLPNTHLD
     AAMGLTALFG LYFIRWFCTQ MGKRYPRQQR AWFFVSTLRM VFIIILYILV SWLVNRHVKD
     PKKAHFKILG HVPSGFQHKG APRLDNEILS AISGDIPTTI LVLLIEHIAI SKSFGRVNNY
     IINPSQELVA IGFTNLLGPF LGGYPATGSF SRTAIKAKAG VRTPLAGIFT AVLVLLALYA
     LTSVFFYIPN SALAAMIIHA VGDLITPPRE VYKFWLTSPL EVVIFFAGVF VSIFTSIENG
     IYVTVAASGA VLLWRIAKSP GKFLGQTEIY TAPRELVRGS KDSGLTQSLL QKSEHHTAFL
     SLDRDDLSNP ELQISTPWPG IFVYRFGEGL NYVNSAKHLD NLTIHVFKHT RRTELNKFEK
     LGDRPWNDPG PRRGQAFLTD ELVSRPTLRA IILDFSAVNC IDVTAAQALQ DLRNQFDRYA
     HPDKVEWHFA GVSNRWTKRA LVASGFGVDS LRTAKVQREN HKGGVQEVDQ GPLVAIGPSV
     SASDIEAVPV GTSGSGSTDE KRPEGEGGAT NGGMEKGSAN GEDISTVPTA TSADACALAR
     DAGGKRLVPV FGINRPFFHI DVATALKSAV RNTGVVAAE
 
 
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