CYS14_NEUCR
ID CYS14_NEUCR Reviewed; 819 AA.
AC P23622; Q7RZ41;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 3.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=Sulfate permease 2;
DE AltName: Full=Sulfate permease II;
GN Name=cys-14; ORFNames=G21B4.280, NCU04433;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1825178; DOI=10.1021/bi00221a008;
RA Ketter J.S., Jarai G., Fu Y.-H., Marzluf G.A.;
RT "Nucleotide sequence, messenger RNA stability, and DNA recognition elements
RT of cys-14, the structural gene for sulfate permease II in Neurospora
RT crassa.";
RL Biochemistry 30:1780-1787(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [4]
RP IDENTIFICATION OF SEQUENCE ERRORS IN SEQUENCE DESCRIBED IN PUBMED:1825178.
RX PubMed=8140616; DOI=10.1016/0968-0004(94)90168-6;
RA Sandal N.N., Marcker K.A.;
RT "Similarities between a soybean nodulin, Neurospora crassa sulphate
RT permease II and a putative human tumour suppressor.";
RL Trends Biochem. Sci. 19:19-19(1994).
CC -!- FUNCTION: Uptake of sulfate into the cell.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Mainly found in mycelia.
CC -!- INDUCTION: Highly expressed, but only in cells subject to sulfur
CC limitation, and it is turned on by the positive-acting 'Cys-3' sulfur
CC regulatory protein.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA33615.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M59167; AAA33615.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BX908808; CAF06013.1; -; Genomic_DNA.
DR EMBL; CM002239; EAA28274.3; -; Genomic_DNA.
DR PIR; A37956; A37956.
DR RefSeq; XP_957510.3; XM_952417.3.
DR AlphaFoldDB; P23622; -.
DR SMR; P23622; -.
DR STRING; 367110.P23622; -.
DR TCDB; 2.A.53.1.2; the sulfate permease (sulp) family.
DR EnsemblFungi; EAA28274; EAA28274; NCU04433.
DR GeneID; 3873616; -.
DR KEGG; ncr:NCU04433; -.
DR VEuPathDB; FungiDB:NCU04433; -.
DR HOGENOM; CLU_003182_8_1_1; -.
DR InParanoid; P23622; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015301; F:anion:anion antiporter activity; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.750.24; -; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; PTHR11814; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SSF52091; 1.
DR TIGRFAMs; TIGR00815; sulP; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..819
FT /note="Sulfate permease 2"
FT /id="PRO_0000080183"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 551..708
FT /note="STAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
FT REGION 726..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 581
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 819 AA; 89321 MW; 965509C1802ECC1A CRC64;
MASTSTAGDR IKKFLGIPAD ERLNDTACYV DGSFVESEPT TQDFLNEIRP TVQGTLNYLR
ELFPFVNWIF HYNLTWLLGD FIAGVTVGFV VVPQGMAYAK LANLAPEYGL YTSFVGFVLY
WAFATSKDIT IGAVAVMSTI VGNIIANVQK DHPDFDAGDI ARTLAFISGA MLLFLGLIRF
GFIVEFIPIV AISAFMTGSA ISIAAGQVST LMGIPNINSR EETYKVIINT LKGLPNTHLD
AAMGLTALFG LYFIRWFCTQ MGKRYPRQQR AWFFVSTLRM VFIIILYILV SWLVNRHVKD
PKKAHFKILG HVPSGFQHKG APRLDNEILS AISGDIPTTI LVLLIEHIAI SKSFGRVNNY
IINPSQELVA IGFTNLLGPF LGGYPATGSF SRTAIKAKAG VRTPLAGIFT AVLVLLALYA
LTSVFFYIPN SALAAMIIHA VGDLITPPRE VYKFWLTSPL EVVIFFAGVF VSIFTSIENG
IYVTVAASGA VLLWRIAKSP GKFLGQTEIY TAPRELVRGS KDSGLTQSLL QKSEHHTAFL
SLDRDDLSNP ELQISTPWPG IFVYRFGEGL NYVNSAKHLD NLTIHVFKHT RRTELNKFEK
LGDRPWNDPG PRRGQAFLTD ELVSRPTLRA IILDFSAVNC IDVTAAQALQ DLRNQFDRYA
HPDKVEWHFA GVSNRWTKRA LVASGFGVDS LRTAKVQREN HKGGVQEVDQ GPLVAIGPSV
SASDIEAVPV GTSGSGSTDE KRPEGEGGAT NGGMEKGSAN GEDISTVPTA TSADACALAR
DAGGKRLVPV FGINRPFFHI DVATALKSAV RNTGVVAAE