CYS15_PLARH
ID CYS15_PLARH Reviewed; 114 AA.
AC A0A6B9KZ52;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 17-JUN-2020, sequence version 1.
DT 03-AUG-2022, entry version 6.
DE RecName: Full=Cystatin Pr15a {ECO:0000303|PubMed:31752210};
DE AltName: Full=Venom cystatin domain peptide Pr15a {ECO:0000312|EMBL:QHB21501.1};
DE Flags: Precursor;
OS Platymeris rhadamanthus (Red spot assassin bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Platymeris.
OX NCBI_TaxID=1134088;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Venom gland;
RX PubMed=31752210; DOI=10.3390/toxins11110673;
RA Walker A.A., Robinson S.D., Undheim E.A.B., Jin J., Han X., Fry B.G.,
RA Vetter I., King G.F.;
RT "Missiles of mass disruption: composition and glandular origin of venom
RT used as a projectile defensive weapon by the assassin bug Platymeris
RT rhadamanthus.";
RL Toxins 11:E673-E673(2019).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:31752210}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland (anterior main gland)
CC (at protein level). {ECO:0000269|PubMed:31752210}.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; MN208312; QHB21501.1; -; mRNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 1: Evidence at protein level;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..114
FT /note="Cystatin Pr15a"
FT /evidence="ECO:0000305"
FT /id="PRO_5025639962"
FT DOMAIN 29..83
FT /note="Cystatin"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 12644 MW; DFECC6C4CDAD3759 CRC64;
MFTVKLLAFM VVAVSLQHLA EATPKVCAGC PVEVDPNRED IKKSLAHVMA AKNSPDELVR
IIKASTQVVN GIKYKVVFEV KNPSTNQVKI CKTAYVSRPW EYEGYNVLEF GCKA