ID   3601L_ASFB7             Reviewed;         360 AA.
AC   P23167;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Protein MGF 360-1L;
GN   OrderedLocusNames=BA71V-003; ORFNames=KP360L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2325203; DOI=10.1128/jvi.64.5.2073-2081.1990;
RA   Gonzalez A., Calvo V., Almazan F., Almendral J.M., Ramirez J.C.,
RA   de la Vega I., Blasco R., Vinuela E.;
RT   "Multigene families in African swine fever virus: family 360.";
RL   J. Virol. 64:2073-2081(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [3]
RP   SEQUENCE REVISION.
RA   Rodriguez J.M., Salas M.L.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=11238833; DOI=10.1128/jvi.75.7.3066-3076.2001;
RA   Zsak L., Lu Z., Burrage T.G., Neilan J.G., Kutish G.F., Moore D.M.,
RA   Rock D.L.;
RT   "African swine fever virus multigene family 360 and 530 genes are novel
RT   macrophage host range determinants.";
RL   J. Virol. 75:3066-3076(2001).
RN   [5]
RP   FUNCTION.
RX   PubMed=14747550; DOI=10.1128/jvi.78.4.1858-1864.2004;
RA   Afonso C.L., Piccone M.E., Zaffuto K.M., Neilan J., Kutish G.F., Lu Z.,
RA   Balinsky C.A., Gibb T.R., Bean T.J., Zsak L., Rock D.L.;
RT   "African swine fever virus multigene family 360 and 530 genes affect host
RT   interferon response.";
RL   J. Virol. 78:1858-1864(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=14963141; DOI=10.1128/jvi.78.5.2445-2453.2004;
RA   Burrage T.G., Lu Z., Neilan J.G., Rock D.L., Zsak L.;
RT   "African swine fever virus multigene family 360 genes affect virus
RT   replication and generalization of infection in Ornithodoros porcinus
RT   ticks.";
RL   J. Virol. 78:2445-2453(2004).
RN   [7]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=Georgia 2007/1;
RX   PubMed=33092258; DOI=10.3390/v12101193;
RA   Ramirez-Medina E., Vuono E.A., Rai A., Pruitt S., Silva E.,
RA   Velazquez-Salinas L., Zhu J., Gladue D.P., Borca M.V.;
RT   "Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the
RT   MGF-360-1L Gene.";
RL   Viruses 12:0-0(2020).
RN   [8]
RP   INDUCTION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages.
CC       {ECO:0000269|PubMed:11238833, ECO:0000269|PubMed:14747550,
CC       ECO:0000269|PubMed:14963141}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:32075923}.
CC   -!- DISRUPTION PHENOTYPE: No effect on virulence.
CC       {ECO:0000269|PubMed:33092258}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 360 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M57546; AAA42683.1; -; Genomic_DNA.
DR   EMBL; U18466; AAA65238.2; -; Genomic_DNA.
DR   PIR; C43680; C43680.
DR   RefSeq; NP_042702.2; NC_001659.2.
DR   SMR; P23167; -.
DR   GeneID; 22220392; -.
DR   KEGG; vg:22220392; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0042330; P:taxis; IEA:InterPro.
DR   InterPro; IPR002595; ASFV_MGF360.
DR   Pfam; PF01671; ASFV_360; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Reference proteome.
FT   CHAIN           1..360
FT                   /note="Protein MGF 360-1L"
FT                   /id="PRO_0000221949"
FT   CONFLICT        202
FT                   /note="R -> P (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        283
FT                   /note="I -> M (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   360 AA;  41733 MW;  F8C84C868B02872B CRC64;
     MPSTLQALTK KVLATQPVFK DDYCILERCG LWWHEAPITI HHTCIDKQIL IKTASFKHGL
     TLNVALMKAV QENNHGLIEL FTEWGADISF GLVTVNMECT QDLCQKLGAR KALSENKILE
     IFYNVQYVKT SSNIILCHEL LSDNPLFLNN AQLKLRIFGE LDTLSINFTL DNISFNEMLT
     RYWYSMAILY KLTEAIQYFY QRYSHFKDWR LICGVAYNNV FDLHEIYNKE KTNIDIDEMM
     QLACMYDCNY TTIYYCCMLG ADINRAMITS VMNFCEGNLF LCIDLGADAF EESMEIASQT
     NNWILINILL FKNYSPDSSL LSIKTTDPEK INALLDEEKY KSKNMLIYEE SLFHIYGVNI