ID   CYSB_FASHE              Reviewed;          32 AA.
AC   P80529; P80531;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Cathepsin B-like cysteine proteinase;
DE            EC=3.4.22.-;
DE   AltName: Full=Newly excysted juvenile proteins 5 and 7;
DE   Flags: Precursor; Fragments;
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7639732; DOI=10.1006/bbrc.1995.2112;
RA   Tkalcevic J., Ashman K., Meeusen E.;
RT   "Fasciola hepatica: rapid identification of newly excysted juvenile
RT   proteins.";
RL   Biochem. Biophys. Res. Commun. 213:169-174(1995).
CC   -!- FUNCTION: Thiol protease.
CC   -!- DEVELOPMENTAL STAGE: Expressed at the newly excysted juvenile stage.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC       ECO:0000255|PROSITE-ProRule:PRU10090}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P80529; -.
DR   DrugBank; DB12245; Triclabendazole.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protease; Thiol protease; Zymogen.
FT   PROPEP          1..>22
FT                   /note="Activation peptide"
FT                   /id="PRO_0000026174"
FT   CHAIN           <23..>32
FT                   /note="Cathepsin B-like cysteine proteinase"
FT                   /id="PRO_0000026175"
FT   NON_CONS        22..23
FT                   /evidence="ECO:0000305"
FT   NON_TER         32
SQ   SEQUENCE   32 AA;  3940 MW;  94BCD2E57BE95CFE CRC64;
     KPNYKRQFEP FSDELIHYIN LEDLPESFDA RQ