ID   CYSB_HAEIN              Reviewed;         323 AA.
AC   P45105;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=HTH-type transcriptional regulator CysB;
DE   AltName: Full=Cys regulon transcriptional activator;
GN   Name=cysB; OrderedLocusNames=HI_1200;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: This protein is a positive regulator of gene expression for
CC       the cysteine regulon. The inducer for CysB is N-acetylserine (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC22854.1; -; Genomic_DNA.
DR   PIR; E64189; E64189.
DR   RefSeq; NP_439356.1; NC_000907.1.
DR   RefSeq; WP_005667393.1; NC_000907.1.
DR   AlphaFoldDB; P45105; -.
DR   SMR; P45105; -.
DR   STRING; 71421.HI_1200; -.
DR   PRIDE; P45105; -.
DR   EnsemblBacteria; AAC22854; AAC22854; HI_1200.
DR   KEGG; hin:HI_1200; -.
DR   PATRIC; fig|71421.8.peg.1252; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_2_6; -.
DR   OMA; FLRTYMY; -.
DR   PhylomeDB; P45105; -.
DR   BioCyc; HINF71421:G1GJ1-1231-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08413; PBP2_CysB_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037423; CysB_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Cysteine biosynthesis; Cytoplasm;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..323
FT                   /note="HTH-type transcriptional regulator CysB"
FT                   /id="PRO_0000105617"
FT   DOMAIN          1..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   323 AA;  36485 MW;  DCFB1F1400FF9886 CRC64;
     MKMHQLRYIV EIVNQNLNVT EAANALYTSQ PGISKQVRLL EDELGLEIFE RHGKHIKSIT
     PAGKKIISIA RELLVKAQGI RAVADEYTRP NHGVLRIATT NTQARYMLPS VIERFSKKYP
     DVSLHIHQGS PTQIHDALMS GEVDLAITTE APYLFDDLVQ IPCYWWNRAV IVSPEHPLAK
     VKELTIEELG KYPLVTYTFG FTGVSDLDYA FNSAGILPNI VFTATDADVI KTYVRLGLGV
     GIMASMAHTA LDTDLVLIDA SHLFRPSMTN IAFKHSTFLR NYMYDFMEYF SPHLTRSVVE
     KAERLRDNNS VKKLFEGIEL ETK