ID   CYSE_BACP2              Reviewed;         217 AA.
AC   A8F961;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Serine acetyltransferase {ECO:0000250|UniProtKB:Q06750};
DE            Short=SAT {ECO:0000250|UniProtKB:Q06750};
DE            EC=2.3.1.30;
GN   Name=cysE {ECO:0000312|EMBL:ABV60778.1}; OrderedLocusNames=BPUM_0078;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1] {ECO:0000312|EMBL:ABV60778.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: Catalyzes the acetylation of serine by acetyl-CoA to produce
CC       O-acetylserine (OAS). {ECO:0000250|UniProtKB:Q06750}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine;
CC         Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30;
CC         Evidence={ECO:0000250|UniProtKB:Q06750};
CC   -!- ACTIVITY REGULATION: Inhibited by cysteine.
CC       {ECO:0000250|UniProtKB:Q06750}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC       from L-serine: step 1/2. {ECO:0000250|UniProtKB:Q06750}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9D4}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000255}.
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DR   EMBL; CP000813; ABV60778.1; -; Genomic_DNA.
DR   RefSeq; WP_012008691.1; NZ_VEIC01000024.1.
DR   AlphaFoldDB; A8F961; -.
DR   SMR; A8F961; -.
DR   STRING; 315750.BPUM_0078; -.
DR   EnsemblBacteria; ABV60778; ABV60778; BPUM_0078.
DR   GeneID; 61744042; -.
DR   KEGG; bpu:BPUM_0078; -.
DR   eggNOG; COG1045; Bacteria.
DR   HOGENOM; CLU_051638_10_0_9; -.
DR   OMA; GDDVMLY; -.
DR   OrthoDB; 1639008at2; -.
DR   UniPathway; UPA00136; UER00199.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009001; F:serine O-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR   CDD; cd03354; LbH_SAT; 1.
DR   Gene3D; 1.10.3130.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR045304; LbH_SAT.
DR   InterPro; IPR010493; Ser_AcTrfase_N.
DR   InterPro; IPR042122; Ser_AcTrfase_N_sf.
DR   InterPro; IPR005881; Ser_O-AcTrfase.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 2.
DR   Pfam; PF06426; SATase_N; 1.
DR   PIRSF; PIRSF000441; CysE; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   TIGRFAMs; TIGR01172; cysE; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Cysteine biosynthesis; Cytoplasm;
KW   Reference proteome; Repeat; Transferase.
FT   CHAIN           1..217
FT                   /note="Serine acetyltransferase"
FT                   /id="PRO_0000404153"
SQ   SEQUENCE   217 AA;  23928 MW;  37356111A83CA141 CRC64;
     MFFKMLKEDI DTVFDQDPAA RSYIEVVLTY SGLHAIWAHR IAHAFYKRKL YFLARIISQV
     SRFFTGVEIH PAATIGRRFF IDHGMGVVIG ETCEIGDNVT VFQGVTLGGT GKEKGKRHPT
     ILDDALIATG AKVLGSITVG KGAKIGAGSV VLKDVPDHST VVGIPGRVVV QNGKKINRDL
     NHQDLPDPIS DRFKELEREM EKLKGELASL SRKEEQS