ID   CYSE_BUCAI              Reviewed;         274 AA.
AC   P57162;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Serine acetyltransferase;
DE            Short=SAT;
DE            EC=2.3.1.30;
GN   Name=cysE; OrderedLocusNames=BU054;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine;
CC         Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC       from L-serine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; BA000003; BAB12777.1; -; Genomic_DNA.
DR   RefSeq; NP_239891.1; NC_002528.1.
DR   RefSeq; WP_009874011.1; NC_002528.1.
DR   AlphaFoldDB; P57162; -.
DR   SMR; P57162; -.
DR   STRING; 107806.10038742; -.
DR   EnsemblBacteria; BAB12777; BAB12777; BAB12777.
DR   KEGG; buc:BU054; -.
DR   PATRIC; fig|107806.10.peg.63; -.
DR   eggNOG; COG1045; Bacteria.
DR   HOGENOM; CLU_051638_0_1_6; -.
DR   OMA; ANCIVLE; -.
DR   UniPathway; UPA00136; UER00199.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009001; F:serine O-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR   CDD; cd03354; LbH_SAT; 1.
DR   Gene3D; 1.10.3130.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR045304; LbH_SAT.
DR   InterPro; IPR010493; Ser_AcTrfase_N.
DR   InterPro; IPR042122; Ser_AcTrfase_N_sf.
DR   InterPro; IPR005881; Ser_O-AcTrfase.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 2.
DR   Pfam; PF06426; SATase_N; 1.
DR   SMART; SM00971; SATase_N; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   TIGRFAMs; TIGR01172; cysE; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Cysteine biosynthesis; Cytoplasm;
KW   Reference proteome; Repeat; Transferase.
FT   CHAIN           1..274
FT                   /note="Serine acetyltransferase"
FT                   /id="PRO_0000068666"
SQ   SEQUENCE   274 AA;  30165 MW;  553D252F1048B6B1 CRC64;
     MCILKISRIW NKILYDVSFL LKKEPILSDF YQSSILQHQS FTSSLSYILS NKLSTSMISE
     KKIQGIFDDV YLNDRSILNF IVQDIKAVLK RDPAVNDYLT PLLYLKGFHA LEAYRISHYL
     WNTGKKSLSL YLQSRISSEF SVDIHPAAFI GSGVMLDHAT GIVIGEGVTI ENDVSILHSV
     TLGGTGKNFS QNRHPTIRKG VVIGAGAKIL GNIEVGSGAK IGAGSIVLKN VPSDVTVVGV
     PAKIVSQVSS KKYYSQKKKN SLKYINIFQH GDGI