CYSE_HAEIN
ID CYSE_HAEIN Reviewed; 267 AA.
AC P43886;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Serine acetyltransferase;
DE Short=SAT;
DE EC=2.3.1.30;
GN Name=cysE; OrderedLocusNames=HI_0606;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine;
CC Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30;
CC -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC from L-serine: step 1/2.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC22265.1; -; Genomic_DNA.
DR PIR; G64080; G64080.
DR RefSeq; NP_438764.1; NC_000907.1.
DR RefSeq; WP_005694542.1; NC_000907.1.
DR PDB; 1S80; X-ray; 2.70 A; A/B/C/D/E/F=2-266.
DR PDB; 1SSM; X-ray; 2.15 A; A/B/C/D/E/F=1-242.
DR PDB; 1SSQ; X-ray; 1.85 A; A/D=1-267.
DR PDB; 1SST; X-ray; 2.00 A; A/B/C=1-267.
DR PDB; 1Y7L; X-ray; 1.55 A; P=258-267.
DR PDBsum; 1S80; -.
DR PDBsum; 1SSM; -.
DR PDBsum; 1SSQ; -.
DR PDBsum; 1SST; -.
DR PDBsum; 1Y7L; -.
DR AlphaFoldDB; P43886; -.
DR SMR; P43886; -.
DR STRING; 71421.HI_0606; -.
DR DrugBank; DB01992; Coenzyme A.
DR DNASU; 949654; -.
DR EnsemblBacteria; AAC22265; AAC22265; HI_0606.
DR KEGG; hin:HI_0606; -.
DR PATRIC; fig|71421.8.peg.630; -.
DR eggNOG; COG1045; Bacteria.
DR HOGENOM; CLU_051638_0_1_6; -.
DR OMA; HPKIRHG; -.
DR PhylomeDB; P43886; -.
DR BioCyc; HINF71421:G1GJ1-625-MON; -.
DR BRENDA; 2.3.1.30; 2529.
DR SABIO-RK; P43886; -.
DR UniPathway; UPA00136; UER00199.
DR EvolutionaryTrace; P43886; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0009001; F:serine O-acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR CDD; cd03354; LbH_SAT; 1.
DR Gene3D; 1.10.3130.10; -; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR045304; LbH_SAT.
DR InterPro; IPR010493; Ser_AcTrfase_N.
DR InterPro; IPR042122; Ser_AcTrfase_N_sf.
DR InterPro; IPR005881; Ser_O-AcTrfase.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF06426; SATase_N; 1.
DR PIRSF; PIRSF000441; CysE; 1.
DR SMART; SM00971; SATase_N; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
DR TIGRFAMs; TIGR01172; cysE; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Amino-acid biosynthesis;
KW Cysteine biosynthesis; Cytoplasm; Reference proteome; Repeat; Transferase.
FT CHAIN 1..267
FT /note="Serine acetyltransferase"
FT /id="PRO_0000068674"
FT HELIX 3..19
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 21..30
FT /evidence="ECO:0007829|PDB:1SSQ"
FT TURN 31..33
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 37..49
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:1SST"
FT HELIX 56..69
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 72..87
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 95..100
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 102..117
FT /evidence="ECO:0007829|PDB:1SSQ"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:1SSQ"
FT HELIX 122..136
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 137..140
FT /evidence="ECO:0007829|PDB:1SST"
FT STRAND 151..154
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:1SST"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:1SST"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 182..184
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 185..187
FT /evidence="ECO:0007829|PDB:1SSM"
FT STRAND 203..207
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 231..233
FT /evidence="ECO:0007829|PDB:1SSQ"
FT TURN 234..237
FT /evidence="ECO:0007829|PDB:1SSQ"
FT STRAND 238..240
FT /evidence="ECO:0007829|PDB:1SST"
FT HELIX 248..251
FT /evidence="ECO:0007829|PDB:1SSQ"
SQ SEQUENCE 267 AA; 29166 MW; 93428DE9D504DFB4 CRC64;
MTLDVWQHIR QEAKELAENE PMLASFFHST ILKHQNLGGA LSYLLANKLA NPIMPAISLR
EIIEEAYQSN PSIIDCAACD IQAVRHRDPA VELWSTPLLY LKGFHAIQSY RITHYLWNQN
RKSLALYLQN QISVAFDVDI HPAAKIGHGI MFDHATGIVV GETSVIENDV SILQGVTLGG
TGKESGDRHP KVREGVMIGA GAKILGNIEV GKYAKIGANS VVLNPVPEYA TAAGVPARIV
SQDKAAKPAF DMNQYFIGID DGMNLNI
