ID   CYSE_HELPY              Reviewed;         171 AA.
AC   P71405;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Serine acetyltransferase;
DE            Short=SAT;
DE            EC=2.3.1.30;
GN   Name=cysE; OrderedLocusNames=HP_1210;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49503 / 60190;
RA   Peek R.M. Jr., Thompson S.A., Atherton J.C., Blaser M.J., Miller G.G.;
RT   "Expression of a novel ulcer-associated gene, iceA, by H. pylori following
RT   contact with gastric epithelium.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine;
CC         Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC       from L-serine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; U43917; AAB07027.1; -; Genomic_DNA.
DR   EMBL; AE000511; AAD08254.1; -; Genomic_DNA.
DR   PIR; B64671; B64671.
DR   RefSeq; NP_208002.1; NC_000915.1.
DR   RefSeq; WP_000886346.1; NC_018939.1.
DR   AlphaFoldDB; P71405; -.
DR   SMR; P71405; -.
DR   STRING; 85962.C694_06265; -.
DR   PaxDb; P71405; -.
DR   EnsemblBacteria; AAD08254; AAD08254; HP_1210.
DR   GeneID; 66522402; -.
DR   KEGG; hpy:HP_1210; -.
DR   PATRIC; fig|85962.47.peg.1301; -.
DR   eggNOG; COG1045; Bacteria.
DR   OMA; GDDVMLY; -.
DR   PhylomeDB; P71405; -.
DR   UniPathway; UPA00136; UER00199.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0009001; F:serine O-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR   CDD; cd03354; LbH_SAT; 1.
DR   Gene3D; 1.10.3130.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR045304; LbH_SAT.
DR   InterPro; IPR042122; Ser_AcTrfase_N_sf.
DR   InterPro; IPR005881; Ser_O-AcTrfase.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 2.
DR   PIRSF; PIRSF000441; CysE; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   TIGRFAMs; TIGR01172; cysE; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Cysteine biosynthesis; Cytoplasm;
KW   Reference proteome; Repeat; Transferase.
FT   CHAIN           1..171
FT                   /note="Serine acetyltransferase"
FT                   /id="PRO_0000068675"
FT   VARIANT         5
FT                   /note="S -> F (in strain: 60190)"
FT   VARIANT         110
FT                   /note="K -> R (in strain: 60190)"
FT   VARIANT         162
FT                   /note="S -> T (in strain: 60190)"
SQ   SEQUENCE   171 AA;  18342 MW;  28646D539C2250C3 CRC64;
     MLDLSYSLER VLQEDPAARN KWEVLLLYPG IHALLCYRLA HALHKRRFYF IARALSQLAR
     FITGIEIHPG AKIGRGLFID HGMGVVIGET TEIGDDVTIY HGVTLGGTGK FKGKRHPTLG
     NRVVVGAGAK VLGAICVGDD VKIGANAVVL SDLPTGSTAV GSKAKTITKD R