ID   CYSE_STAES              Reviewed;         213 AA.
AC   Q8CTU2;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Serine acetyltransferase;
DE            Short=SAT;
DE            EC=2.3.1.30;
GN   Name=cysE; OrderedLocusNames=SE_0291;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-serine = CoA + O-acetyl-L-serine;
CC         Xref=Rhea:RHEA:24560, ChEBI:CHEBI:33384, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:58340; EC=2.3.1.30;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC       from L-serine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; AE015929; AAO03888.1; -; Genomic_DNA.
DR   RefSeq; NP_763846.1; NC_004461.1.
DR   RefSeq; WP_001832254.1; NZ_WBME01000014.1.
DR   AlphaFoldDB; Q8CTU2; -.
DR   SMR; Q8CTU2; -.
DR   STRING; 176280.SE_0291; -.
DR   EnsemblBacteria; AAO03888; AAO03888; SE_0291.
DR   GeneID; 50019543; -.
DR   KEGG; sep:SE_0291; -.
DR   PATRIC; fig|176280.10.peg.267; -.
DR   eggNOG; COG1045; Bacteria.
DR   HOGENOM; CLU_051638_10_0_9; -.
DR   OMA; GDDVMLY; -.
DR   UniPathway; UPA00136; UER00199.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009001; F:serine O-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR   CDD; cd03354; LbH_SAT; 1.
DR   Gene3D; 1.10.3130.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR045304; LbH_SAT.
DR   InterPro; IPR042122; Ser_AcTrfase_N_sf.
DR   InterPro; IPR005881; Ser_O-AcTrfase.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 2.
DR   PIRSF; PIRSF000441; CysE; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   TIGRFAMs; TIGR01172; cysE; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Cysteine biosynthesis; Cytoplasm;
KW   Repeat; Transferase.
FT   CHAIN           1..213
FT                   /note="Serine acetyltransferase"
FT                   /id="PRO_0000068683"
SQ   SEQUENCE   213 AA;  23679 MW;  D3CA34E5F46C415C CRC64;
     MLKRMRDDIK MVFEQDPAAR STLEVITTYA GLHAVWSHLI AHKLYKNRRY VAARMISQLS
     RFFTGIEIHP GAKIGKRLFI DHGMGVVIGE TCTIGDNVTI YQGVTLGGTG KEKGKRHPDI
     GDNVLIAAGS KILGNIKIES NVNIGANSVV LQSVPSYTTV VGIPGHIVKQ EGRRIGKTFD
     HRNLPDPLYE QIKHLERQLE KAKNGEIQDD YII