ID   ACSC_KOMXY              Reviewed;        1302 AA.
AC   P37718;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Cellulose synthase operon protein C;
DE   Flags: Precursor;
GN   Name=acsC;
OS   Komagataeibacter xylinus (Gluconacetobacter xylinus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Komagataeibacter.
OX   NCBI_TaxID=28448;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 53582 / NQ5;
RX   PubMed=8083166; DOI=10.1128/jb.176.18.5735-5752.1994;
RA   Saxena I.M., Kudlicka K., Okuda K., Brown R.M. Jr.;
RT   "Characterization of genes in the cellulose-synthesizing operon (acs
RT   operon) of Acetobacter xylinum: implications for cellulose
RT   crystallization.";
RL   J. Bacteriol. 176:5735-5752(1994).
RN   [2]
RP   TOPOLOGY.
RX   PubMed=11544230; DOI=10.1128/jb.183.19.5668-5674.2001;
RA   Kimura S., Chen H.P., Saxena I.M., Brown R.M. Jr., Itoh T.;
RT   "Localization of c-di-GMP-binding protein with the linear terminal
RT   complexes of Acetobacter xylinum.";
RL   J. Bacteriol. 183:5668-5674(2001).
CC   -!- FUNCTION: Required for maximal bacterial cellulose synthesis. It may be
CC       involved in the formation of a membrane complex for extrusion of the
CC       cellulose product.
CC   -!- PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AcsC/BcsC family. {ECO:0000305}.
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DR   EMBL; X54676; CAA38489.1; -; Genomic_DNA.
DR   AlphaFoldDB; P37718; -.
DR   UniPathway; UPA00694; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR008410; BCSC_C.
DR   InterPro; IPR003921; Cell_synth_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF05420; BCSC_C; 1.
DR   PRINTS; PR01441; CELLSNTHASEC.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   1: Evidence at protein level;
KW   c-di-GMP; Cell outer membrane; Cellulose biosynthesis; Membrane; Repeat;
KW   Signal; TPR repeat.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..1302
FT                   /note="Cellulose synthase operon protein C"
FT                   /id="PRO_0000035685"
FT   REPEAT          64..97
FT                   /note="TPR 1"
FT   REPEAT          147..180
FT                   /note="TPR 2"
FT   REPEAT          306..339
FT                   /note="TPR 3"
FT   REPEAT          340..373
FT                   /note="TPR 4"
FT   REPEAT          572..605
FT                   /note="TPR 5"
FT   REPEAT          716..749
FT                   /note="TPR 6"
FT   REPEAT          750..783
FT                   /note="TPR 7"
SQ   SEQUENCE   1302 AA;  138751 MW;  CC1E32F0E1F9D794 CRC64;
     MTHKRYASSL SAGLLATTCV AGLLLQANGA RAQQAAEAQA PASSTTMMQA ATVAPAQSGQ
     AAVVQRLVQQ ARFWMQQHQY ENARQSLQSA ARLAPDSVDL LEAEGEYQSH IGNRDAALDT
     QRRLHQAAPG STYESQLNDL LHEQAISQPD LAHARSLAAS GHSDQAVEAY QHLFNGSTPT
     PSLAVEYYQT LAGVSGQAGT AQDGLIRLVK ANPSDFRAQL ALAQVLTYQP GTRMEGLQRL
     QALQKYQSSA PVEAATAEKS YRQTLSWLPV TPETLPLMQK WLDAHPSDSA LRTHMAEPAG
     GPPDKGALAR QDGFKALNAG RLSAAQAAFQ SALNLNAKDG DALGGLGLVA MRAGHNEEAH
     RYLEDAIAAD PKNAAHWRPA LAGMAVGEEY GSVRRLIASG QTQEAEQRLM TLARQPGQSE
     GATLMLADLQ RSTGQTGEAE RNYRAILARN GDNPIALMGL ARVLMGEGQE SEANALLSRL
     GGRYSDQVQQ IEVSGIMAEA ARTSDSAQKV SLLRQAMTKA PDDPWLRINL ANALQQQGDS
     AEAANVMRPL LTSPRTPADY QAAILYASGN GNDTLARRLL AGLSPDDYSP AIRTIADEMA
     IKADLASRLS MVSNPTPLVR EALAAPDPTG ARGVAVADLF RQRGDMLHAH MALRIASTRN
     IDLTTEQRLA YATEYMKISN PVAAARLLAP LGDGSGTATG SAMSPDQRQT LMQLRMGISV
     AQSDLLNQRG DQAAAYDHLA PALQADPEAT SPKLALARLY NGRGKYGHAL DIDLAVLRHN
     PQDLDARQAA VQAAANDGKD NLAMQLAQDG VQQSPMDARS WLGMAVADRA VGHGDRTLAD
     LRRAYELRLQ QLKISRGDAI GGDETQATAP PTANPFRRDA YGHALSLGAP PGENGYSTAG
     SVPEISDQML SSINGQIHTL SEDMAPSVDA GLGFRVRSGT PGMGALTEAS VPIVGRIPLQ
     AGTSALTFTA TPTFLTSGHL PQTGYDIPRF GTNLFALERN LQNQNNSAEH RINTDTIGRE
     AGVAPDVRFA NNWVSADVGA SPLGFTLPNV IGGVEFAPRV GPVTFRVSGE RRSITNSVLS
     YGGMTDALTG KKWGGVVTNH FHGQVEATLG NTIVYGGGGY AIQTGHHVQS NTEVEGGLGA
     NTLVYRNRKH EVRVGVNLTY FGYKHNEDFY TYGQGGYFSP QSYFAATVPV RYSGHSGLFD
     WDVTGSIGYQ LFHEHSSAFF PTNPVYQALA NGLAGVSTAE LSLESARYPG DDVGSLVGGF
     DGRVGYRVSH SLRLDLSGRF QKAGNWDEGG AMISAHYLIM DQ