ID   ACSF1_THEVB             Reviewed;         380 AA.
AC   Q8DJ05;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1 {ECO:0000255|HAMAP-Rule:MF_01840};
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1 {ECO:0000255|HAMAP-Rule:MF_01840};
DE            EC=1.14.13.81 {ECO:0000255|HAMAP-Rule:MF_01840};
GN   Name=acsF1 {ECO:0000255|HAMAP-Rule:MF_01840}; OrderedLocusNames=tlr1426;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in chlorophyll
CC       biosynthesis. Mediates the cyclase reaction, which results in the
CC       formation of divinylprotochlorophyllide (Pchlide) characteristic of all
CC       chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester
CC       (MgPMME). {ECO:0000255|HAMAP-Rule:MF_01840}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH +
CC         3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+);
CC         Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=1.14.13.81;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01840};
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01840};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC       biosynthesis (light-independent). {ECO:0000255|HAMAP-Rule:MF_01840}.
CC   -!- SIMILARITY: Belongs to the AcsF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01840}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC08978.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000039; BAC08978.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_682216.1; NC_004113.1.
DR   AlphaFoldDB; Q8DJ05; -.
DR   STRING; 197221.22295150; -.
DR   EnsemblBacteria; BAC08978; BAC08978; BAC08978.
DR   KEGG; tel:tlr1426; -.
DR   PATRIC; fig|197221.4.peg.1498; -.
DR   eggNOG; COG1633; Bacteria.
DR   OMA; FHPIFKW; -.
DR   OrthoDB; 366541at2; -.
DR   UniPathway; UPA00670; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0036068; P:light-independent chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-UniRule.
DR   CDD; cd01047; ACSF; 1.
DR   HAMAP; MF_01840; AcsF; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR009078; Ferritin-like_SF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   PANTHER; PTHR31053; PTHR31053; 2.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   SUPFAM; SSF47240; SSF47240; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Iron; Metal-binding; NADP; Oxidoreductase;
KW   Photosynthesis; Reference proteome.
FT   CHAIN           1..380
FT                   /note="Magnesium-protoporphyrin IX monomethyl ester
FT                   [oxidative] cyclase 1"
FT                   /id="PRO_0000217535"
SQ   SEQUENCE   380 AA;  45481 MW;  86C8DC83BBDFAF73 CRC64;
     MVNTVAKPEF EELRPGIKAP AKETILTPRF YTTDFEAMAN MDITENKAEL EAILEEFRCD
     YNRHHFVRDE EFEQSWDHID GETRRLFIEF LERSCTAEFS GFLLYKELSR RLKDRNPLLA
     ECFALMSRDE ARHAGFLNKA MADFNLSLDL GFLTQHRSYT YFEPEFIFYA TYLSEKIGYW
     RYITIYRHLE KHPEHRIYPI FRFFENWCQD ENRHGDFFDA VMRAQPQMLD RPRTFWQKIK
     EIPLSLSGKK WARYFMVCWV PPKLWCRFFL LSVFATMYLN DLQRAKFYTA LGLDAREYDR
     EVIAKTNETA GRVFPVILDV DHPEFYQRLE RCVENNAKLT EIAKQNGGFL KKLPLYLSNV
     WQMIKLFLIP AKEPTRVAVR