ID   CYSLP_CLABA             Reviewed;         165 AA.
AC   M1GL27;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Cystatin-like protein {ECO:0000312|EMBL:AGD94422.1};
DE   AltName: Full=CbCystatin {ECO:0000303|PubMed:23246809};
DE   Flags: Precursor;
OS   Clarias batrachus (Walking catfish) (Silurus batrachus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Clariidae; Clarias.
OX   NCBI_TaxID=59899;
RN   [1] {ECO:0000312|EMBL:AGD94422.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, DOMAIN, AND PHYLOGENETIC
RP   ANALYSIS.
RC   TISSUE=Head kidney {ECO:0000303|PubMed:23246809};
RX   PubMed=23246809; DOI=10.1016/j.fsi.2012.11.018;
RA   Mohindra V., Tripathi R.K., Singh A., Singh B.;
RT   "Molecular characterization and expression analysis of a novel cystatin-
RT   like gene in a hypoxia-tolerant Indian catfish, Clarias batrachus
RT   [Linnaeus, 1758].";
RL   Fish Shellfish Immunol. 34:683-687(2013).
CC   -!- FUNCTION: Involved in hypoxia tolerance. {ECO:0000269|PubMed:23246809}.
CC   -!- INDUCTION: By oxidation stress as a result of either short or long
CC       periods of environmental hypoxia. {ECO:0000269|PubMed:23246809}.
CC   -!- DOMAIN: Seems to have a cystatin/monellin-like domain.
CC       {ECO:0000303|PubMed:23246809}.
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DR   EMBL; JX020765; AGD94422.1; -; mRNA.
DR   AlphaFoldDB; M1GL27; -.
DR   PRIDE; M1GL27; -.
DR   GO; GO:0033555; P:multicellular organismal response to stress; IEP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Signal; Stress response.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..165
FT                   /note="Cystatin-like protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434474"
FT   DISULFID        80..92
FT                   /evidence="ECO:0000250|UniProtKB:Q8NFT8"
FT   DISULFID        104..118
FT                   /evidence="ECO:0000250|UniProtKB:Q8NFT8"
SQ   SEQUENCE   165 AA;  18492 MW;  86EFB89715971892 CRC64;
     MDVALKLLLL AALTLLASAQ TPIDYKDLST TLQEHIDKAL EEGNRKFGGR HHVALDSFVT
     PAVTRQSILN VNVFLKVTTC MKTRSYKHRP ECNTQKRSTP KINCLVCKMK NGTELVHCAR
     KIDILHGEHK EIRDNCDVTR IGVSSLMAQT MPDDYRKQVG CLGCI