ID   CYSO_MYCTO              Reviewed;          93 AA.
AC   P9WP32; L0T9C0; P0A646; Q10646;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Sulfur carrier protein CysO;
DE   AltName: Full=9.5 kDa culture filtrate antigen cfp10A;
GN   Name=cysO; Synonyms=cfp10A; OrderedLocusNames=MT1376.1;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: In its thiocarboxylated form (CysO-COSH), is the sulfur donor
CC       in the CysM-dependent cysteine biosynthetic pathway. May be of
CC       particular importance for cysteine biosynthesis in the persistent phase
CC       of M.tuberculosis (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis.
CC   -!- SIMILARITY: Belongs to the sulfur carrier protein CysO family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45641.1; -; Genomic_DNA.
DR   PIR; C70771; C70771.
DR   RefSeq; WP_003406910.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WP32; -.
DR   SMR; P9WP32; -.
DR   EnsemblBacteria; AAK45641; AAK45641; MT1376.1.
DR   GeneID; 45425313; -.
DR   KEGG; mtc:MT1376.1; -.
DR   PATRIC; fig|83331.31.peg.1484; -.
DR   HOGENOM; CLU_114601_1_0_11; -.
DR   UniPathway; UPA00136; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR016155; Mopterin_synth/thiamin_S_b.
DR   InterPro; IPR003749; ThiS/MoaD-like.
DR   Pfam; PF02597; ThiS; 1.
DR   SUPFAM; SSF54285; SSF54285; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cysteine biosynthesis.
FT   CHAIN           1..93
FT                   /note="Sulfur carrier protein CysO"
FT                   /id="PRO_0000427022"
SQ   SEQUENCE   93 AA;  9557 MW;  CA53151BC14742A8 CRC64;
     MNVTVSIPTI LRPHTGGQKS VSASGDTLGA VISDLEANYS GISERLMDPS SPGKLHRFVN
     IYVNDEDVRF SGGLATAIAD GDSVTILPAV AGG