ID   CYSP3_OSTOS             Reviewed;         174 AA.
AC   Q06544;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cathepsin B-like cysteine proteinase 3;
DE            EC=3.4.22.-;
DE   Flags: Fragment;
GN   Name=CP-3;
OS   Ostertagia ostertagi (Brown stomach worm) (Strongylus ostertagi).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Haemonchidae; Ostertagia.
OX   NCBI_TaxID=6317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Larva;
RX   PubMed=1475000; DOI=10.1016/0166-6851(92)90152-a;
RA   Pratt D., Boisvenue R.J., Cox G.N.;
RT   "Isolation of putative cysteine protease genes of Ostertagia ostertagi.";
RL   Mol. Biochem. Parasitol. 56:39-48(1992).
CC   -!- FUNCTION: Expression of the protease correlates with blood-feeding and
CC       suggests a role for the protease in blood digestion.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC       ECO:0000255|PROSITE-ProRule:PRU10090}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M88505; AAA29436.1; -; Genomic_DNA.
DR   PIR; B48454; B48454.
DR   AlphaFoldDB; Q06544; -.
DR   SMR; Q06544; -.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hydrolase; Protease; Thiol protease; Zymogen.
FT   CHAIN           <1..174
FT                   /note="Cathepsin B-like cysteine proteinase 3"
FT                   /id="PRO_0000050535"
FT   ACT_SITE        122
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        142
FT                   /evidence="ECO:0000250"
FT   DISULFID        22..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..42
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   174 AA;  19939 MW;  1C309D3D11135EF3 CRC64;
     AWQYFALEGV VTGGNYRKQG CCRPYEFPPC GRHGKEPYYG ECYDTAKTPK CQKTCQRGYL
     KAYKEDKHFG KSAYRLPNNV KAIQRDIMKN GPVVAGFIVY EDFAHYKSGI YKHTAGRMTG
     GHAVKIIGWG KEKGTPYWLI ANSWHDDWGE KGFYRMIRGI NNCRIEEMVF AGIV