ACSF_SYNPW
ID ACSF_SYNPW Reviewed; 360 AA.
AC A5GKR3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase {ECO:0000255|HAMAP-Rule:MF_01840};
DE Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase {ECO:0000255|HAMAP-Rule:MF_01840};
DE EC=1.14.13.81 {ECO:0000255|HAMAP-Rule:MF_01840};
GN Name=acsF {ECO:0000255|HAMAP-Rule:MF_01840};
GN OrderedLocusNames=SynWH7803_1102;
OS Synechococcus sp. (strain WH7803).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=32051;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH7803;
RG Genoscope;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the formation of the isocyclic ring in chlorophyll
CC biosynthesis. Mediates the cyclase reaction, which results in the
CC formation of divinylprotochlorophyllide (Pchlide) characteristic of all
CC chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester
CC (MgPMME). {ECO:0000255|HAMAP-Rule:MF_01840}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH +
CC 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+);
CC Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=1.14.13.81;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01840};
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01840};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC biosynthesis (light-independent). {ECO:0000255|HAMAP-Rule:MF_01840}.
CC -!- SIMILARITY: Belongs to the AcsF family. {ECO:0000255|HAMAP-
CC Rule:MF_01840}.
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DR EMBL; CT971583; CAK23528.1; -; Genomic_DNA.
DR RefSeq; WP_011933010.1; NC_009481.1.
DR AlphaFoldDB; A5GKR3; -.
DR SMR; A5GKR3; -.
DR STRING; 32051.SynWH7803_1102; -.
DR EnsemblBacteria; CAK23528; CAK23528; SynWH7803_1102.
DR KEGG; syx:SynWH7803_1102; -.
DR eggNOG; COG1633; Bacteria.
DR HOGENOM; CLU_048037_0_0_3; -.
DR OMA; FHPIFKW; -.
DR OrthoDB; 366541at2; -.
DR UniPathway; UPA00670; -.
DR Proteomes; UP000001566; Chromosome.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0036068; P:light-independent chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-UniRule.
DR CDD; cd01047; ACSF; 1.
DR HAMAP; MF_01840; AcsF; 1.
DR InterPro; IPR008434; AcsF.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR003251; Rubrerythrin.
DR PANTHER; PTHR31053; PTHR31053; 1.
DR Pfam; PF02915; Rubrerythrin; 1.
DR SUPFAM; SSF47240; SSF47240; 1.
DR TIGRFAMs; TIGR02029; AcsF; 1.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis; Iron; Metal-binding; NADP; Oxidoreductase;
KW Photosynthesis; Reference proteome.
FT CHAIN 1..360
FT /note="Magnesium-protoporphyrin IX monomethyl ester
FT [oxidative] cyclase"
FT /id="PRO_1000070553"
SQ SEQUENCE 360 AA; 41422 MW; 66465D9F7D744B03 CRC64;
MVPPTAVNDA PAAGSAVSVK DPAKDTILTP RFYTTDFEAM AAMDLRPNEA ELEAICEEFR
KDYNRHHFVR NDEFEGAADK LDPETRRVFV EFLEQSCTSE FSGFLLYKEL SRRIKTRNPL
LAECFAHMAR DEARHAGFLN KSMSDFGLQL DLGFLTANKS YTFFQPKFIF YATYLSEKIG
YWRYITIFRH LEKNPDSKIF PIFNFFENWC QDENRHGDFF DALMKAQPNT VRGFRARLWC
RFFLLAVFAT MYVRDVARKE FYEALGLDAR DYDRLVIDKT NETTARVFPV VLDVKNPKFY
AGLENLVTNN AALDAVDASA SSAPIKVLRK LPHWIANGAQ MASLFLMAPV RSESFQPSVR
