ID   CYSR_SYNE7              Reviewed;         206 AA.
AC   P27369; Q31MK5;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Regulatory protein CysR;
GN   Name=cysR; OrderedLocusNames=Synpcc7942_1684;
OS   Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS   R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1708375; DOI=10.1128/jb.173.9.2739-2750.1991;
RA   Laudenbach D.E., Grossman A.R.;
RT   "Characterization and mutagenesis of sulfur-regulated genes in a
RT   cyanobacterium: evidence for function in sulfate transport.";
RL   J. Bacteriol. 173:2739-2750(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably regulates the expression of genes from the sulfate
CC       permease complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By sulfur deprivation.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M65247; AAA73046.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB57714.1; -; Genomic_DNA.
DR   RefSeq; WP_011244716.1; NC_007604.1.
DR   AlphaFoldDB; P27369; -.
DR   SMR; P27369; -.
DR   STRING; 1140.Synpcc7942_1684; -.
DR   PRIDE; P27369; -.
DR   EnsemblBacteria; ABB57714; ABB57714; Synpcc7942_1684.
DR   KEGG; syf:Synpcc7942_1684; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_075053_8_1_3; -.
DR   OMA; HKKVEAM; -.
DR   OrthoDB; 1596937at2; -.
DR   BioCyc; SYNEL:SYNPCC7942_1684-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008272; P:sulfate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Stress response; Sulfate transport; Transcription;
KW   Transcription regulation; Transport.
FT   CHAIN           1..206
FT                   /note="Regulatory protein CysR"
FT                   /id="PRO_0000100153"
FT   DOMAIN          120..196
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        156..175
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
SQ   SEQUENCE   206 AA;  22760 MW;  21B57BE397EA7E44 CRC64;
     MVREPASTLL PPTSPATPAP HRLLIGRRGM VPTGANVIWK IQSGLVRSST WGEEGDMISL
     GLWGPGDLIG RPLSCLDPYE LECLTAVEVV AVSDPALESH ESLVRSLRYT ERLLSITRLR
     RAEAKLASLL GWIGERFGQP GATGWEIDLR RIPLTHQVIA ELSGSTRVTT TRLLGEFRQA
     GRIHRRDRAL IVRYPETLYP PARLSA