CYST_SALTY
ID CYST_SALTY Reviewed; 277 AA.
AC P41032;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Sulfate transport system permease protein CysT;
GN Name=cysU; Synonyms=cysT; OrderedLocusNames=STM2443;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
RC STRAIN=LT2;
RX PubMed=1909324; DOI=10.1128/jb.173.18.5876-5886.1991;
RA Hryniewicz M.M., Kredich N.M.;
RT "The cysP promoter of Salmonella typhimurium: characterization of two
RT binding sites for CysB protein, studies of in vivo transcription
RT initiation, and demonstration of the anti-inducer effects of thiosulfate.";
RL J. Bacteriol. 173:5876-5886(1991).
CC -!- FUNCTION: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1)
CC involved in sulfate/thiosulfate import. Probably responsible for the
CC translocation of the substrate across the membrane (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CysA),
CC two transmembrane proteins (CysT and CysW) and a solute-binding protein
CC (CysP). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; AE006468; AAL21337.1; -; Genomic_DNA.
DR RefSeq; NP_461378.1; NC_003197.2.
DR RefSeq; WP_000881745.1; NC_003197.2.
DR AlphaFoldDB; P41032; -.
DR SMR; P41032; -.
DR STRING; 99287.STM2443; -.
DR PaxDb; P41032; -.
DR EnsemblBacteria; AAL21337; AAL21337; STM2443.
DR GeneID; 1253965; -.
DR KEGG; stm:STM2443; -.
DR PATRIC; fig|99287.12.peg.2581; -.
DR HOGENOM; CLU_016047_14_0_6; -.
DR OMA; VFISGNM; -.
DR PhylomeDB; P41032; -.
DR BioCyc; SENT99287:STM2443-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015419; F:ABC-type sulfate transporter activity; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR011865; CysT_permease.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR005667; Sulph_transpt2.
DR PANTHER; PTHR30406; PTHR30406; 1.
DR PANTHER; PTHR30406:SF10; PTHR30406:SF10; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR00969; 3a0106s02; 1.
DR TIGRFAMs; TIGR02139; permease_CysT; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sulfate transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..277
FT /note="Sulfate transport system permease protein CysT"
FT /id="PRO_0000059990"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 188..205
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 60..263
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 277 AA; 30183 MW; 8C22531C99E50748 CRC64;
MLAVSSRRVL PGFTLSLGTS LLFVCLILLL PLSALVMQLS QMSWAQYWDV VTNPQVVAAY
KVTLLAAFVA SIFNGVFGLL MAWILTRYRF PGRTLLDALM DLPFALPTAV AGLTLASLFS
VNGFYGQFLA QFDIKVTYTW LGIAVAMAFT SIPFVVRTVQ PVLEELGPEY EEAAQTLGAT
RLQSFRKVVL PELSPALIAG VALSFTRSLG EFGAVIFIAG NIAWKTEVTS LMIFVRLQEF
DYPAASAIAS VILAASLLLL FSINTLQSRF GRRVVGH
