CYSW_ECOL6
ID CYSW_ECOL6 Reviewed; 291 AA.
AC P0AEB1; P16702; P76534;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Sulfate transport system permease protein CysW;
GN Name=cysW; OrderedLocusNames=c2957;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1)
CC involved in sulfate/thiosulfate import. Probably responsible for the
CC translocation of the substrate across the membrane.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CysA),
CC two transmembrane proteins (CysT and CysW) and a solute-binding protein
CC (CysP). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; AE014075; AAN81407.1; -; Genomic_DNA.
DR RefSeq; WP_000852686.1; NC_004431.1.
DR AlphaFoldDB; P0AEB1; -.
DR SMR; P0AEB1; -.
DR STRING; 199310.c2957; -.
DR EnsemblBacteria; AAN81407; AAN81407; c2957.
DR GeneID; 66673707; -.
DR KEGG; ecc:c2957; -.
DR eggNOG; COG4208; Bacteria.
DR HOGENOM; CLU_016047_14_0_6; -.
DR OMA; NEYNFVA; -.
DR BioCyc; ECOL199310:C2957-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015419; F:ABC-type sulfate transporter activity; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR011866; CysW_permease.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR005667; Sulph_transpt2.
DR PANTHER; PTHR30406; PTHR30406; 1.
DR PANTHER; PTHR30406:SF9; PTHR30406:SF9; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR00969; 3a0106s02; 1.
DR TIGRFAMs; TIGR02140; permease_CysW; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sulfate transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..291
FT /note="Sulfate transport system permease protein CysW"
FT /id="PRO_0000059998"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 44..69
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 91..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 126..141
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 163..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 222..247
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 269..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 66..270
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 291 AA; 32538 MW; 1878BEA4EB3F6E67 CRC64;
MAEVTQLKRY DARPINWGKW FLIGIGMLVS AFILLVPMIY IFVQAFSKGL MPVLQNLADP
DMLHAIWLTV MIALIAVPVN LVFGILLAWL VTRFNFPGRQ LLLTLLDIPF AVSPVVAGLV
YLLFYGSNGP LGGWLDEHNL QIMFSWPGMV LVTIFVTCPF VVRELVPVML SQGSQEDEAA
ILLGASGWQM FRRVTLPNIR WALLYGVVLT NARAIGEFGA VSVVSGSIRG ETLSLPLQIE
LLEQDYNTVG SFTAAALLTL MAIITLFLKS MLQWRLENQE KRAQQEEHHE H