ID   CYSZ_HAEI8              Reviewed;         272 AA.
AC   Q4QLI8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN   Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468}; OrderedLocusNames=NTHI1268;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC       transporter, which mediates sulfate uptake. Provides the sulfur source
CC       for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00468}.
CC   -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC       Rule:MF_00468}.
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DR   EMBL; CP000057; AAX88109.1; -; Genomic_DNA.
DR   RefSeq; WP_011272386.1; NC_007146.2.
DR   AlphaFoldDB; Q4QLI8; -.
DR   SMR; Q4QLI8; -.
DR   EnsemblBacteria; AAX88109; AAX88109; NTHI1268.
DR   KEGG; hit:NTHI1268; -.
DR   HOGENOM; CLU_070331_1_0_6; -.
DR   OMA; PFADDWS; -.
DR   OrthoDB; 1972181at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR   HAMAP; MF_00468; CysZ; 1.
DR   InterPro; IPR022985; Sulfate_CysZ.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW   Cysteine biosynthesis; Membrane; Sulfate transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..272
FT                   /note="Sulfate transporter CysZ"
FT                   /id="PRO_0000204341"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ   SEQUENCE   272 AA;  31196 MW;  71C0663D382B3931 CRC64;
     MLNLNELKSG FHYFVMGWHF ITQKGLRRFV IIPILLNTIL LCGLFWLFIS QISSAIDWVM
     NFIPDWLSFL SVILLTLSIL TILLLFYFTF TTFSGFIAAP FNGLLAEKVE KMLTEENIND
     DSLVDIMRDV PRMLAREWQK LRYSLPKIIA LFLLSFIPLV GQTIVPVLTF LFTCWMMAIQ
     YCDYPFDNHK VSFDIMKTAL GNQRTQSLTF GGLVTCCTFV PVINLLIMPV AVCGATLMWV
     ENYRNDLGFN MNRSFSSQTG LDVRSENTGI VK