CYSZ_HAEIG
ID CYSZ_HAEIG Reviewed; 272 AA.
AC A5UIM8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN OrderedLocusNames=CGSHiGG_09160;
OS Haemophilus influenzae (strain PittGG).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=374931;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PittGG;
RX PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA Ehrlich G.D.;
RT "Characterization and modeling of the Haemophilus influenzae core and
RT supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT nontypeable strains.";
RL Genome Biol. 8:R103.1-R103.18(2007).
CC -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC transporter, which mediates sulfate uptake. Provides the sulfur source
CC for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
CC -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
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DR EMBL; CP000672; ABR00634.1; -; Genomic_DNA.
DR RefSeq; WP_012055398.1; NC_009567.1.
DR AlphaFoldDB; A5UIM8; -.
DR SMR; A5UIM8; -.
DR EnsemblBacteria; ABR00634; ABR00634; CGSHiGG_09160.
DR KEGG; hiq:CGSHiGG_09160; -.
DR HOGENOM; CLU_070331_1_0_6; -.
DR OMA; PFADDWS; -.
DR Proteomes; UP000001990; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR HAMAP; MF_00468; CysZ; 1.
DR InterPro; IPR022985; Sulfate_CysZ.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW Cysteine biosynthesis; Membrane; Sulfate transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..272
FT /note="Sulfate transporter CysZ"
FT /id="PRO_1000013714"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ SEQUENCE 272 AA; 31143 MW; D6855A61C1496A43 CRC64;
MLNLNELKSG FHYFVMGWHF ITQKGLRRFV IMPIVLNTIL LCGLFWLFIS QISSAIDWMM
NFIPDWLSFL SVILLTLSIL TILLLFYFTF TTFSGFIAAP FNGLLAEKVE KMLTGENIND
DGLVDIMRDV PRMLAREWQK LRYSLPKIIA LFLLSFIPLV GQTIVPVLTF LFTCWMMAIQ
YCDYPFDNHK VSFDIMKNAL GNQRTQSLTF GGLVTCCTFV PVINLLIMPV AVCGATLMWV
ENYRNDLGFN MNRSFSSQTG LDVRSENTGI VK