CYSZ_PECAS
ID CYSZ_PECAS Reviewed; 275 AA.
AC Q6D8S7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468}; OrderedLocusNames=ECA0895;
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRI 1043 / ATCC BAA-672;
RX PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT subsp. atroseptica and characterization of virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC transporter, which mediates sulfate uptake. Provides the sulfur source
CC for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
CC -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
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DR EMBL; BX950851; CAG73807.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6D8S7; -.
DR SMR; Q6D8S7; -.
DR STRING; 218491.ECA0895; -.
DR DNASU; 2882625; -.
DR EnsemblBacteria; CAG73807; CAG73807; ECA0895.
DR KEGG; eca:ECA0895; -.
DR eggNOG; COG2981; Bacteria.
DR HOGENOM; CLU_070331_1_0_6; -.
DR OMA; PFADDWS; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR HAMAP; MF_00468; CysZ; 1.
DR InterPro; IPR022985; Sulfate_CysZ.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW Cysteine biosynthesis; Membrane; Reference proteome; Sulfate transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..275
FT /note="Sulfate transporter CysZ"
FT /id="PRO_0000204339"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31321 MW; 7193638E0F732EE5 CRC64;
MSSEKSSFPE KPPSFEKPSH SNTADHTRSG VHYFFAGWRL ISLPGIRRFV ILPLLMNIVL
MGGAFWWLFT QLNDWIPQIM SHIPSWLQWL SYLIWPLAVL SILLVFSYLF STIANFIAAP
FNGLLAEQLE AKLTGQTLPD SGILSIAKDV PRIMKREVQK LAYYLPRAIV LLLLYFIPGI
GQTVAPVLWF LFSAWMLAIQ YCDYPFDNHK VGFSTMRQAL RRHKVANMQF GALVSLFTLV
PFLNLVIMPV AVCGATQLWV DRYRNLSATL PKKSP
