ID   CYSZ_SALTY              Reviewed;         253 AA.
AC   P12673;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN   Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468}; OrderedLocusNames=STM2429;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=3290198; DOI=10.1128/jb.170.7.3150-3157.1988;
RA   Byrne C.R., Monroe R.S., Ward K.A., Kredich N.M.;
RT   "DNA sequences of the cysK regions of Salmonella typhimurium and
RT   Escherichia coli and linkage of the cysK regions to ptsH.";
RL   J. Bacteriol. 170:3150-3157(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Possibly involved in sulfate transport.
CC   -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC       transporter, which mediates sulfate uptake. Provides the sulfur source
CC       for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00468}.
CC   -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC       Rule:MF_00468}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA27050.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M21450; AAA27050.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE006468; AAL21323.1; -; Genomic_DNA.
DR   PIR; A28181; BVEBCZ.
DR   RefSeq; NP_461364.1; NC_003197.2.
DR   RefSeq; WP_000255006.1; NC_003197.2.
DR   AlphaFoldDB; P12673; -.
DR   SMR; P12673; -.
DR   STRING; 99287.STM2429; -.
DR   PaxDb; P12673; -.
DR   EnsemblBacteria; AAL21323; AAL21323; STM2429.
DR   GeneID; 1253951; -.
DR   KEGG; stm:STM2429; -.
DR   PATRIC; fig|99287.12.peg.2566; -.
DR   HOGENOM; CLU_070331_1_0_6; -.
DR   OMA; PFADDWS; -.
DR   PhylomeDB; P12673; -.
DR   BioCyc; SENT99287:STM2429-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0009675; F:high-affinity sulfate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0000103; P:sulfate assimilation; IBA:GO_Central.
DR   HAMAP; MF_00468; CysZ; 1.
DR   InterPro; IPR022985; Sulfate_CysZ.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW   Cysteine biosynthesis; Membrane; Reference proteome; Sulfate transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..253
FT                   /note="Sulfate transporter CysZ"
FT                   /id="PRO_0000204349"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ   SEQUENCE   253 AA;  28907 MW;  101B2E26D48CC285 CRC64;
     MVSSSTTVPR SGVYYFSQGW KLVTLPGIRR FVILPLLVNI VLMGGAFWWL FTQLDAWIPS
     LMSHVPDWLQ WLSYLLWPIA VISVLLVFGY FFSTLANWIA APFNGLLAEQ LEARLTGATP
     PDTGILGIMK DVPRIMKREW QKLAWYLPRA IVLLILYFIP GIGQTIAPVL WFLFSAWMLA
     IQYCDYPFDN HKVPFKTMRA ALRTQKVANM QFGALTSLFT MIPVLNLFIM PVAVCGATAM
     WVDCWRAKHA LWK