CYSZ_SHIB3
ID CYSZ_SHIB3 Reviewed; 253 AA.
AC B2TWZ5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN OrderedLocusNames=SbBS512_E2767;
OS Shigella boydii serotype 18 (strain CDC 3083-94 / BS512).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=344609;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 3083-94 / BS512;
RA Rasko D.A., Rosovitz M., Maurelli A.T., Myers G., Seshadri R., Cer R.,
RA Jiang L., Ravel J., Sebastian Y.;
RT "Complete sequence of Shigella boydii serotype 18 strain BS512.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC transporter, which mediates sulfate uptake. Provides the sulfur source
CC for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
CC -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
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DR EMBL; CP001063; ACD08844.1; -; Genomic_DNA.
DR RefSeq; WP_000254839.1; NC_010658.1.
DR AlphaFoldDB; B2TWZ5; -.
DR SMR; B2TWZ5; -.
DR STRING; 344609.SbBS512_E2767; -.
DR EnsemblBacteria; ACD08844; ACD08844; SbBS512_E2767.
DR KEGG; sbc:SbBS512_E2767; -.
DR HOGENOM; CLU_070331_1_0_6; -.
DR OMA; PFADDWS; -.
DR Proteomes; UP000001030; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR HAMAP; MF_00468; CysZ; 1.
DR InterPro; IPR022985; Sulfate_CysZ.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW Cysteine biosynthesis; Membrane; Sulfate transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..253
FT /note="Sulfate transporter CysZ"
FT /id="PRO_1000125505"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ SEQUENCE 253 AA; 29305 MW; 057C4908D9FBB453 CRC64;
MVSSFTSAPR SGFYYFAQGW KLVSQPGIRR FVILPLLVNI LLMGGAFWWL FTQLDVWIPT
LMSYVPDWLQ WLSYLLWPLA VISVLLVFGY FFSTIANWIA APFNGLLAEQ LEARLTGATP
PDTGIFGIMK DVPRIMKREW QKFAWYLPRA IVLLILYFIP GIGQTVAPVL WFLFSAWMLA
IQYCDYPFDN HKVPFKEMRT ALRTRKITNM QFGALTSLFT MIPLLNLFIM PVAVCGATAM
WVDCYRDKHA MWR