CYSZ_VIBC3
ID CYSZ_VIBC3 Reviewed; 250 AA.
AC A5F2W1; C3LYY0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN OrderedLocusNames=VC0395_A0490, VC395_0984;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC transporter, which mediates sulfate uptake. Provides the sulfur source
CC for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
CC -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
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DR EMBL; CP000627; ABQ20415.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP08996.1; -; Genomic_DNA.
DR RefSeq; WP_001167409.1; NZ_JAACZH010000005.1.
DR AlphaFoldDB; A5F2W1; -.
DR SMR; A5F2W1; -.
DR STRING; 345073.VC395_0984; -.
DR EnsemblBacteria; ABQ20415; ABQ20415; VC0395_A0490.
DR KEGG; vco:VC0395_A0490; -.
DR KEGG; vcr:VC395_0984; -.
DR PATRIC; fig|345073.21.peg.953; -.
DR eggNOG; COG2981; Bacteria.
DR HOGENOM; CLU_070331_1_0_6; -.
DR OMA; PFADDWS; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR HAMAP; MF_00468; CysZ; 1.
DR InterPro; IPR022985; Sulfate_CysZ.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW Cysteine biosynthesis; Membrane; Sulfate transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..250
FT /note="Sulfate transporter CysZ"
FT /id="PRO_1000072390"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ SEQUENCE 250 AA; 28427 MW; B7E431ED1A3780E1 CRC64;
MQISSRSGFG YFSYGIRLAL TPGIRRFVVL PLLANIILVG GAMYYLFSHL DTWISEWIGQ
LPSFLSWLSY VLWPLLALTI LATFSYFFST LANFIASPFN GLLAEKVEQH LSGERIGEEG
VWALVKDVPR ILSREWRKLL YVLPKALGLF LLLLIPALGQ TLGPIAWFLF TAWMLAIQYC
DYPFDNHKIS FHDMRNTLKQ NQSKAYGFGM LVAFFTSIPI VNLFIVPVAV CGATAMWVME
FKTQHSPLRQ
