CYT3_ORYSJ
ID CYT3_ORYSJ Reviewed; 184 AA.
AC Q6I570; A0A0P0WM62;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Cysteine proteinase inhibitor 3;
DE AltName: Full=Oryzacystatin III;
DE Short=OC-III;
DE AltName: Full=Oryzacystatin-3;
DE Flags: Precursor;
GN OrderedLocusNames=Os05g0409300, LOC_Os05g33880; ORFNames=OSJNBb0014K18.11;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=15887031; DOI=10.1007/s00438-005-1147-4;
RA Martinez M., Abraham Z., Carbonero P., Diaz I.;
RT "Comparative phylogenetic analysis of cystatin gene families from
RT arabidopsis, rice and barley.";
RL Mol. Genet. Genomics 273:423-432(2005).
CC -!- FUNCTION: Specific inhibitor of cysteine proteinases. Probably involved
CC in the regulation of endogenous processes and in defense against pests
CC and pathogens (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cystatin family. Phytocystatin subfamily.
CC {ECO:0000305}.
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DR EMBL; AC137620; AAT58854.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF17441.1; -; Genomic_DNA.
DR EMBL; AP014961; BAS93984.1; -; Genomic_DNA.
DR EMBL; AK065214; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015640576.1; XM_015785090.1.
DR AlphaFoldDB; Q6I570; -.
DR SMR; Q6I570; -.
DR STRING; 4530.OS05T0409300-01; -.
DR MEROPS; I25.053; -.
DR PaxDb; Q6I570; -.
DR PRIDE; Q6I570; -.
DR EnsemblPlants; Os05t0409300-01; Os05t0409300-01; Os05g0409300.
DR GeneID; 4338771; -.
DR Gramene; Os05t0409300-01; Os05t0409300-01; Os05g0409300.
DR KEGG; osa:4338771; -.
DR eggNOG; ENOG502R76J; Eukaryota.
DR HOGENOM; CLU_113093_1_0_1; -.
DR InParanoid; Q6I570; -.
DR OMA; RTHSHNS; -.
DR OrthoDB; 1565344at2759; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR ExpressionAtlas; Q6I570; baseline and differential.
DR Genevisible; Q6I570; OS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR027214; Cystatin.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR11413; PTHR11413; 1.
DR Pfam; PF16845; SQAPI; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 2: Evidence at transcript level;
KW Plant defense; Protease inhibitor; Reference proteome; Secreted; Signal;
KW Thiol protease inhibitor.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..184
FT /note="Cysteine proteinase inhibitor 3"
FT /id="PRO_0000277500"
FT DOMAIN 48..134
FT /note="Cystatin"
FT REGION 138..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 90..94
FT /note="Secondary area of contact"
FT /evidence="ECO:0000250"
FT SITE 39
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT CONFLICT 80
FT /note="E -> G (in Ref. 5; AK065214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 19665 MW; 87A5B99089C71D1C CRC64;
MLRRRGFCCC SGAPAAAAAA LLLLAVAAAA PRAAGFHLGG DESVLVRGML AAIRREQAEA
EDAARFAVAE YNKNQGAELE FARIVKAKRQ VVTGTLHDLM LEVVDSGKKS LYSAKVWVKP
WLDFKAVVEF RHVGDSQSQS ATAADDNAGQ DTADPTVASR NDLHNTENNK VSVVLSTFSQ
TYSV
