ID   CYT4_NEUCR              Reviewed;        1117 AA.
AC   P47950; Q7RVJ7;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Mitochondrial protein cyt-4;
GN   Name=cyt-4; ORFNames=NCU09327;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=1311848; DOI=10.1073/pnas.89.5.1676;
RA   Turcq B., Dobinson K.F., Serizawa N., Lambowitz A.M.;
RT   "A protein required for RNA processing and splicing in Neurospora
RT   mitochondria is related to gene products involved in cell cycle protein
RT   phosphatase functions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:1676-1680(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for RNA 5'- and 3'-end processing and splicing. May
CC       act on the RNA processing enzymes directly, or it may act on other
CC       regulatory molecules, which influence the activity or synthesis of
CC       these enzymes.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
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DR   EMBL; M80735; AAA33608.1; -; Genomic_DNA.
DR   EMBL; CM002236; EAA34685.3; -; Genomic_DNA.
DR   PIR; A38227; A38227.
DR   RefSeq; XP_963921.3; XM_958828.3.
DR   AlphaFoldDB; P47950; -.
DR   STRING; 5141.EFNCRP00000009141; -.
DR   PRIDE; P47950; -.
DR   EnsemblFungi; EAA34685; EAA34685; NCU09327.
DR   GeneID; 3880070; -.
DR   KEGG; ncr:NCU09327; -.
DR   VEuPathDB; FungiDB:NCU09327; -.
DR   HOGENOM; CLU_002512_0_1_1; -.
DR   InParanoid; P47950; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   Pfam; PF00773; RNB; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; Reference proteome.
FT   CHAIN           1..1117
FT                   /note="Mitochondrial protein cyt-4"
FT                   /id="PRO_0000166418"
FT   REGION          705..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1117 AA;  125104 MW;  93D1832D9128B20B CRC64;
     MMRPSSRQPY VCWQCLSRKD SGQHIALNTR KARVASLSSL ASWPISSASI APRPTRQWDR
     TLRLFRERRQ GLSTSTSLLG RKIPEISNEA LEDFALPLEP DLQHLQDSQP KTTKRSAHLS
     IRQRLKQWEA ENPEPFHSIP SDFALPDRPI NAFTSKRSEH MLEIENIDND NATAQVHDQD
     LIDTQVTPRV QAGDLVELKS EDWNIGVLAV CLGSFNGIDH FYAVTGKWFA SSNFKSGFIV
     KNFITNSADL QPVIGALPST VGDMSILVEL QKLRAGPTRE HGAGLITKML DFQNTSRQIY
     QSNLERLSNP HRHLPEEEQL MTLGEIAEFL LPPKLKQSST GFPPAALYAV YNNIRTFFDD
     FFHPLGQGTA GPSSIIFHVA ARSDIENVAR VERMVRDHYS PELLDRKSRR EHDRLEPVLR
     QARLAIDHSR KMREWSSHGM LGPTTRVLPA STYSWSQDAL TVIGVIHMWA ASDVFPRSSK
     YQWIGAAVLR ALGRYQDADV LDATVGWTFL QEIGWLMPWE IHARHSLRLP GLQVNRAGGL
     LPSPEEQQPA ELDEDVLAPL RQDFYTSTVY CIDAPNAKEI DDGVSLEKTD KEGEYWIHVH
     IADPTSRIRP DSSLAKRAAL MTQTSYLPGH VDKMISDEAV VAEFSLAPGR PSLTFSARLN
     EEGTLLDHKV TPGRIGDVVY ITPQDVATAV GPVDAGIPKV STPDVVLEVG TPPSAEDEAP
     TRKMTKPDEL SEQNVKDLEI LSRLAAAIHK VRIQKGSVPI FLPSPSADFS LVNARIEHTP
     SGFLACTNDP YISVKYSVSG GLHPIVDDLM GTANQIAALW CYERGIPIPF RTNLLAAQNE
     EALRAYTQDV IYPQLIAGKQ PSLEEMRTLR NLLGGHDIAA TPTFIYTMGV DIYTKATSPL
     RRYSDLLVHW QIQAALLEEH KRLAQGSQSL VIRKFDKYHL KPPMDDKQAA RLGLPFTASH
     LENKVFPHLR VRERHAKTLA NIDGRNELIL QALVRAWRFG EGKEGQVPEK FTYTVVNVQN
     TCVRGRIDYF DLWAEIDLDN LAGFSLLSNM RAGDVLTVQL ADVNVHMRKI VVKPVEFVQR
     GPERGRLFAE EQEGEGEVEN GGEYIDVEHE VLQPQGR