CYT7_ARATH
ID CYT7_ARATH Reviewed; 232 AA.
AC Q8LC76; Q9FF63;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Cysteine proteinase inhibitor 7;
DE Short=AtCYS-7;
DE Flags: Precursor;
GN Name=CYS7; OrderedLocusNames=At5g05110; ORFNames=MUG13.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15887031; DOI=10.1007/s00438-005-1147-4;
RA Martinez M., Abraham Z., Carbonero P., Diaz I.;
RT "Comparative phylogenetic analysis of cystatin gene families from
RT arabidopsis, rice and barley.";
RL Mol. Genet. Genomics 273:423-432(2005).
CC -!- FUNCTION: Specific inhibitor of cysteine proteinases. Probably involved
CC in the regulation of endogenous processes and in defense against pests
CC and pathogens (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cystatin family. Phytocystatin subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63801.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB005245; BAB11533.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90829.1; -; Genomic_DNA.
DR EMBL; AF370168; AAK43983.1; -; mRNA.
DR EMBL; AY059130; AAL15236.1; -; mRNA.
DR EMBL; AY086750; AAM63801.1; ALT_INIT; mRNA.
DR RefSeq; NP_196130.1; NM_120593.3.
DR AlphaFoldDB; Q8LC76; -.
DR SMR; Q8LC76; -.
DR STRING; 3702.AT5G05110.1; -.
DR MEROPS; I25.958; -.
DR PaxDb; Q8LC76; -.
DR PRIDE; Q8LC76; -.
DR ProteomicsDB; 220463; -.
DR EnsemblPlants; AT5G05110.1; AT5G05110.1; AT5G05110.
DR GeneID; 830393; -.
DR Gramene; AT5G05110.1; AT5G05110.1; AT5G05110.
DR KEGG; ath:AT5G05110; -.
DR Araport; AT5G05110; -.
DR TAIR; locus:2175294; AT5G05110.
DR eggNOG; ENOG502SJ6Y; Eukaryota.
DR HOGENOM; CLU_072701_1_0_1; -.
DR InParanoid; Q8LC76; -.
DR OMA; DMRRASM; -.
DR OrthoDB; 1565344at2759; -.
DR PhylomeDB; Q8LC76; -.
DR PRO; PR:Q8LC76; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LC76; baseline and differential.
DR Genevisible; Q8LC76; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 2.
DR InterPro; IPR027214; Cystatin.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR11413; PTHR11413; 1.
DR Pfam; PF00031; Cystatin; 1.
DR Pfam; PF16845; SQAPI; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 2.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Plant defense; Protease inhibitor; Reference proteome;
KW Repeat; Secreted; Signal; Thiol protease inhibitor.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..232
FT /note="Cysteine proteinase inhibitor 7"
FT /id="PRO_0000277499"
FT DOMAIN 46..135
FT /note="Cystatin 1"
FT DOMAIN 152..214
FT /note="Cystatin 2"
FT MOTIF 91..95
FT /note="Secondary area of contact"
FT /evidence="ECO:0000250"
FT SITE 46
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT MOD_RES 181
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8H0X6"
SQ SEQUENCE 232 AA; 26582 MW; 419354AACBF07115 CRC64;
MDMRRASMCM MLICVSLVLL SGFGQFVICS EEKGTYNDNV VKMKLGGFSD SKNDWNGGKE
IDDIALFAVQ EHNRRENAVL ELARVLKATE QVVAGKLYRL TLEVIEAGEK KIYEAKVWVK
PWMNFKQLQE FKNIIPSFTI SDLGFKPDGN GFDWRSVSTN NPEVQEAAKH AMKSLQQKSN
SLFPYKLIDI ILARAKVVEE RVKFELLLKL ERGNKLEKFM VEVMKDQTGK YE
