ID   CYTA1_PIG               Reviewed;         103 AA.
AC   Q28988;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Cystatin-A1;
DE   AltName: Full=Stefin-A1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RA   Pungercar J., Strukelj B.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 3-103.
RC   TISSUE=Skin;
RX   PubMed=8898076; DOI=10.1016/0014-5793(96)00984-2;
RA   Lenarcic B., Krizaj I., Zunec P., Turk V.;
RT   "Differences in specificity for the interactions of stefins A, B and D with
RT   cysteine proteinases.";
RL   FEBS Lett. 395:113-118(1996).
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; U41734; AAB03263.1; -; mRNA.
DR   RefSeq; NP_999024.1; NM_213859.1.
DR   AlphaFoldDB; Q28988; -.
DR   SMR; Q28988; -.
DR   STRING; 9823.ENSSSCP00000022174; -.
DR   MEROPS; I25.001; -.
DR   PaxDb; Q28988; -.
DR   PeptideAtlas; Q28988; -.
DR   Ensembl; ENSSSCT00045023122; ENSSSCP00045015966; ENSSSCG00045013537.
DR   GeneID; 396866; -.
DR   KEGG; ssc:396866; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   OrthoDB; 1647595at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW   Reference proteome; Thiol protease inhibitor.
FT   CHAIN           1..103
FT                   /note="Cystatin-A1"
FT                   /id="PRO_0000207130"
FT   MOTIF           51..55
FT                   /note="Secondary area of contact"
FT   SITE            10
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11650 MW;  69E36BAABCC19123 CRC64;
     MESDKMMPGG LTEARPATPE IQEIATTVKS QLEEKTNKTY EKFEAVEYKS QVVAGINYYI
     KVHVGGNSYV HIKVFKSLPY QNKPLELSGY QVDKTKDDEL TGF