ID   CYTA5_PIG               Reviewed;         103 AA.
AC   Q28986;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Cystatin-A5;
DE   AltName: Full=Stefin-A5;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RA   Pungercar J., Strukelj B.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; U41732; AAB03261.1; -; mRNA.
DR   AlphaFoldDB; Q28986; -.
DR   SMR; Q28986; -.
DR   MEROPS; I25.001; -.
DR   Ensembl; ENSSSCT00070015473; ENSSSCP00070012797; ENSSSCG00070008013.
DR   Ensembl; ENSSSCT00070015486; ENSSSCP00070012809; ENSSSCG00070008013.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 13.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protease inhibitor; Reference proteome;
KW   Thiol protease inhibitor.
FT   CHAIN           1..103
FT                   /note="Cystatin-A5"
FT                   /id="PRO_0000207131"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           51..55
FT                   /note="Secondary area of contact"
FT   SITE            10
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11743 MW;  9F4FDE8580AAEB44 CRC64;
     MESEEMLAGG LTEPRPATPE IQEIANKVKP QLEEKTKKTY EKFEAIIYRS QVVAGTNYYI
     KVHVGGNSYV HIIVFQNLPQ LNEPLKLIGY QVDKTKDDEL TSF