ID   CYTA8_PIG               Reviewed;         103 AA.
AC   Q28987;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cystatin-A8;
DE   AltName: Full=Stefin-A8;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RA   Pungercar J., Strukelj B.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U41733; AAB03262.1; -; mRNA.
DR   RefSeq; NP_999025.1; NM_213860.1.
DR   AlphaFoldDB; Q28987; -.
DR   SMR; Q28987; -.
DR   STRING; 9823.ENSSSCP00000027834; -.
DR   MEROPS; I25.001; -.
DR   PaxDb; Q28987; -.
DR   PRIDE; Q28987; -.
DR   Ensembl; ENSSSCT00000054923; ENSSSCP00000038637; ENSSSCG00000028871.
DR   Ensembl; ENSSSCT00045036833; ENSSSCP00045025617; ENSSSCG00045021547.
DR   GeneID; 396867; -.
DR   KEGG; ssc:396867; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   GeneTree; ENSGT00940000155717; -.
DR   OrthoDB; 1647595at2759; -.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000028871; Expressed in penis and 30 other tissues.
DR   ExpressionAtlas; Q28987; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protease inhibitor; Reference proteome;
KW   Thiol protease inhibitor.
FT   CHAIN           1..103
FT                   /note="Cystatin-A8"
FT                   /id="PRO_0000207132"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           51..55
FT                   /note="Secondary area of contact"
FT   SITE            10
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11713 MW;  9F521E8580AAEB44 CRC64;
     MESEEMLAGG LTEPRPATPE IQEIANKVKP QLEEKTKKTY EKFEAIIYRS QVVAGTNYYI
     KVHVGGNSYV HIIVFQNLPQ LNEPLKLIGY QVDKTKDDEL TGF