ID   CYTA_BOVIN              Reviewed;          98 AA.
AC   P80416;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Cystatin-A;
DE   AltName: Full=Cystatin-AS;
DE   AltName: Full=Stefin-A;
GN   Name=CSTA; Synonyms=STF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin;
RX   PubMed=7875311; DOI=10.1016/0014-5793(95)00060-m;
RA   Turk B., Ritonja A., Bjoerk I., Stoka V., Dolenc I., Turk V.;
RT   "Identification of bovine stefin A, a novel protein inhibitor of cysteine
RT   proteinases.";
RL   FEBS Lett. 360:101-105(1995).
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   PIR; S69086; S69086.
DR   AlphaFoldDB; P80416; -.
DR   SMR; P80416; -.
DR   STRING; 9913.ENSBTAP00000014138; -.
DR   MEROPS; I25.001; -.
DR   PaxDb; P80416; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   InParanoid; P80416; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW   Reference proteome; Thiol protease inhibitor.
FT   CHAIN           1..98
FT                   /note="Cystatin-A"
FT                   /id="PRO_0000207126"
FT   MOTIF           46..50
FT                   /note="Secondary area of contact"
FT   SITE            4
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P01039"
SQ   SEQUENCE   98 AA;  11124 MW;  DDD369ED45728374 CRC64;
     MIPGGLTEAK PATIEIQEIA NMVKPQLEEK TNETYEEFTA IEYKSQVVAG INYYIKIQTG
     DNRYIHIKVF KSLPQQSHSL ILTGYQVDKT KDDELAGF