CYTA_MOUSE
ID CYTA_MOUSE Reviewed; 97 AA.
AC P56567; Q3UV05;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Cystatin-A;
DE AltName: Full=Cystatin-A1;
DE AltName: Full=Stefin-A;
GN Name=Csta; Synonyms=Csta1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; AK137702; BAE23468.1; -; mRNA.
DR CCDS; CCDS37327.1; -.
DR RefSeq; NP_001028411.1; NM_001033239.3.
DR AlphaFoldDB; P56567; -.
DR SMR; P56567; -.
DR BioGRID; 229065; 2.
DR ComplexPortal; CPX-100; Cathepsin-B - cystatin-A complex.
DR STRING; 10090.ENSMUSP00000093795; -.
DR MEROPS; I25.001; -.
DR PhosphoSitePlus; P56567; -.
DR MaxQB; P56567; -.
DR PaxDb; P56567; -.
DR PRIDE; P56567; -.
DR ProteomicsDB; 279257; -.
DR DNASU; 209294; -.
DR Ensembl; ENSMUST00000096090; ENSMUSP00000093795; ENSMUSG00000034362.
DR GeneID; 209294; -.
DR KEGG; mmu:209294; -.
DR UCSC; uc007zcf.1; mouse.
DR CTD; 209294; -.
DR MGI; MGI:3524930; Csta1.
DR VEuPathDB; HostDB:ENSMUSG00000034362; -.
DR eggNOG; ENOG502SF2X; Eukaryota.
DR GeneTree; ENSGT00940000155717; -.
DR HOGENOM; CLU_150234_2_1_1; -.
DR InParanoid; P56567; -.
DR OMA; INYFIKM; -.
DR OrthoDB; 1647595at2759; -.
DR PhylomeDB; P56567; -.
DR TreeFam; TF333174; -.
DR BioGRID-ORCS; 209294; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Csta1; mouse.
DR PRO; PR:P56567; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P56567; protein.
DR Bgee; ENSMUSG00000034362; Expressed in tail skin and 39 other tissues.
DR ExpressionAtlas; P56567; baseline and differential.
DR Genevisible; P56567; MM.
DR GO; GO:0001533; C:cornified envelope; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:1904090; C:peptidase inhibitor complex; ISO:MGI.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; ISO:MGI.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0098609; P:cell-cell adhesion; ISO:MGI.
DR GO; GO:0030216; P:keratinocyte differentiation; ISO:MGI.
DR GO; GO:0010466; P:negative regulation of peptidase activity; ISO:MGI.
DR GO; GO:0045861; P:negative regulation of proteolysis; ISO:MGI.
DR GO; GO:0018149; P:peptide cross-linking; ISO:MGI.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR InterPro; IPR001713; Prot_inh_stefin.
DR PANTHER; PTHR11414; PTHR11414; 1.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 3: Inferred from homology;
KW Acetylation; Cytoplasm; Protease inhibitor; Reference proteome;
KW Thiol protease inhibitor.
FT CHAIN 1..97
FT /note="Cystatin-A"
FT /id="PRO_0000207149"
FT MOTIF 46..50
FT /note="Secondary area of contact"
FT /evidence="ECO:0000250"
FT SITE 4
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P01039"
SQ SEQUENCE 97 AA; 10929 MW; 5EDBAA66E81F76EC CRC64;
MIPGGLTEAR PATAEVQEIA DRVKAQLEEE TNEKYEIFKA VEYKTQVVAG VNYFIKMDVG
GGCFTHIKVF KDLSGKNNLE LTGYQTNKTE DDELTYF
