CYTB_BOVIN
ID CYTB_BOVIN Reviewed; 98 AA.
AC P25417; Q32PC6;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Cystatin-B;
DE AltName: Full=Stefin-B;
GN Name=CSTB; Synonyms=CST6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
RC TISSUE=Thymus;
RX PubMed=1544453; DOI=10.1016/0014-5793(92)80066-p;
RA Krizaj I., Turk B., Turk V.;
RT "The complete primary structure of bovine stefin B.";
RL FEBS Lett. 298:237-239(1992).
RN [2]
RP PROTEIN SEQUENCE.
RC TISSUE=Thymus;
RX PubMed=1515072; DOI=10.1515/bchm3.1992.373.2.441;
RA Turk B., Krizaj I., Turk V.;
RT "Isolation and characterization of bovine stefin B.";
RL Biol. Chem. Hoppe-Seyler 373:441-446(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC -!- SUBUNIT: Able to form dimers stabilized by noncovalent forces.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC108169; AAI08170.1; -; mRNA.
DR PIR; S20421; S20421.
DR RefSeq; NP_001032538.1; NM_001037461.2.
DR AlphaFoldDB; P25417; -.
DR SMR; P25417; -.
DR STRING; 9913.ENSBTAP00000000683; -.
DR MEROPS; I25.003; -.
DR iPTMnet; P25417; -.
DR PaxDb; P25417; -.
DR PeptideAtlas; P25417; -.
DR PRIDE; P25417; -.
DR GeneID; 512805; -.
DR KEGG; bta:512805; -.
DR CTD; 1476; -.
DR eggNOG; ENOG502SF2X; Eukaryota.
DR HOGENOM; CLU_150234_2_0_1; -.
DR InParanoid; P25417; -.
DR OrthoDB; 1647595at2759; -.
DR TreeFam; TF333174; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR InterPro; IPR001713; Prot_inh_stefin.
DR PANTHER; PTHR11414; PTHR11414; 1.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW Reference proteome; Thiol protease inhibitor.
FT CHAIN 1..98
FT /note="Cystatin-B"
FT /id="PRO_0000207134"
FT MOTIF 46..50
FT /note="Secondary area of contact"
FT SITE 4
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|PubMed:1544453"
FT CONFLICT 90
FT /note="G -> S (in Ref. 3; AAI08170)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 11140 MW; 091F048791E193F7 CRC64;
MMCGGTSATQ PATAETQAIA DKVKSQLEEK ENKKFPVFKA LEFKSQLVAG KNYFIKVQVD
EDDFVHIRVF ESLPHENKPV ALTSYQTNKG RHDELTYF
