ID   CYTB_PANPA              Reviewed;          98 AA.
AC   P60575;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Cystatin-B;
DE   AltName: Full=Stefin-B;
GN   Name=CSTB; Synonyms=STFB;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12573263; DOI=10.1016/s0888-7543(02)00010-1;
RA   Osawa M., Kaneko M., Horiuchi H., Kitano T., Kawamoto Y., Saitou N.,
RA   Umetsu K.;
RT   "Evolution of the cystatin B gene: implications for the origin of its
RT   variable dodecamer tandem repeat in humans.";
RL   Genomics 81:78-84(2003).
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly
CC       binding reversible inhibitor of cathepsins L, H and B (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Able to form dimers stabilized by noncovalent forces.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; AB083087; BAC20306.1; -; Genomic_DNA.
DR   AlphaFoldDB; P60575; -.
DR   BMRB; P60575; -.
DR   SMR; P60575; -.
DR   STRING; 9597.XP_008975988.1; -.
DR   MEROPS; I25.003; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Nucleus; Protease inhibitor; Reference proteome;
KW   Thiol protease inhibitor.
FT   CHAIN           1..98
FT                   /note="Cystatin-B"
FT                   /id="PRO_0000207138"
FT   MOTIF           46..50
FT                   /note="Secondary area of contact"
FT                   /evidence="ECO:0000250"
FT   SITE            4
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P25417, ECO:0000305"
SQ   SEQUENCE   98 AA;  11140 MW;  B8076220E19D0483 CRC64;
     MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG
     DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF