CYTB_PIG
ID CYTB_PIG Reviewed; 98 AA.
AC Q29290;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Cystatin-B;
DE AltName: Full=Stefin-B;
GN Name=CSTB; Synonyms=CST6, STFB;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
RC TISSUE=Thymus;
RX PubMed=8898076; DOI=10.1016/0014-5793(96)00984-2;
RA Lenarcic B., Krizaj I., Zunec P., Turk V.;
RT "Differences in specificity for the interactions of stefins A, B and D with
RT cysteine proteinases.";
RL FEBS Lett. 395:113-118(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-98.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; F14641; CAA23174.1; -; mRNA.
DR AlphaFoldDB; Q29290; -.
DR SMR; Q29290; -.
DR STRING; 9823.ENSSSCP00000021841; -.
DR MEROPS; I25.003; -.
DR iPTMnet; Q29290; -.
DR PaxDb; Q29290; -.
DR PeptideAtlas; Q29290; -.
DR PRIDE; Q29290; -.
DR Ensembl; ENSSSCT00000023178; ENSSSCP00000021841; ENSSSCG00000027357.
DR Ensembl; ENSSSCT00025012535; ENSSSCP00025004962; ENSSSCG00025009470.
DR Ensembl; ENSSSCT00035022666; ENSSSCP00035008343; ENSSSCG00035017614.
DR Ensembl; ENSSSCT00045031108; ENSSSCP00045021566; ENSSSCG00045018269.
DR Ensembl; ENSSSCT00055039725; ENSSSCP00055031599; ENSSSCG00055020262.
DR Ensembl; ENSSSCT00070015906; ENSSSCP00070013153; ENSSSCG00070008242.
DR VGNC; VGNC:97952; CSTB.
DR eggNOG; ENOG502SF2X; Eukaryota.
DR GeneTree; ENSGT00940000154826; -.
DR InParanoid; Q29290; -.
DR OMA; AAYQTNK; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Proteomes; UP000314985; Chromosome 13.
DR Bgee; ENSSSCG00000027357; Expressed in subcutaneous adipose tissue and 43 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR InterPro; IPR001713; Prot_inh_stefin.
DR PANTHER; PTHR11414; PTHR11414; 1.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW Reference proteome; Thiol protease inhibitor.
FT CHAIN 1..98
FT /note="Cystatin-B"
FT /id="PRO_0000207142"
FT MOTIF 46..50
FT /note="Secondary area of contact"
FT /evidence="ECO:0000250"
FT SITE 4
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|PubMed:8898076"
SQ SEQUENCE 98 AA; 11131 MW; 92673DEEF1C7E93C CRC64;
MMCGAPSATQ PATAEIQAIA DKVKSQLEEK ENKTFPVFKA VEFKSQVVAG RNLFIKVQVD
DDDFVHLRVF ESLPHENKPL TLSSYQTNKS RHDELTYF
