ID   CYTB_SHEEP              Reviewed;          98 AA.
AC   Q10994;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Cystatin-B;
DE   AltName: Full=Stefin-B;
GN   Name=CSTB; Synonyms=CST6;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=8759291; DOI=10.1016/0305-0491(96)00010-7;
RA   Ritonja A., Coetzer T.H.T., Pike R.N., Dennison C.;
RT   "The amino acid sequences, structure comparisons and inhibition kinetics of
RT   sheep cathepsin L and sheep stefin B.";
RL   Comp. Biochem. Physiol. 114B:193-198(1996).
CC   -!- FUNCTION: This is an intracellular thiol proteinase inhibitor.
CC   -!- SUBUNIT: Able to form dimers stabilized by noncovalent forces.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q10994; -.
DR   SMR; Q10994; -.
DR   STRING; 9940.ENSOARP00000012223; -.
DR   MEROPS; I25.003; -.
DR   Ensembl; ENSOART00020009164; ENSOARP00020007576; ENSOARG00020005932.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW   Reference proteome; Thiol protease inhibitor.
FT   CHAIN           1..98
FT                   /note="Cystatin-B"
FT                   /id="PRO_0000207144"
FT   MOTIF           46..50
FT                   /note="Secondary area of contact"
FT                   /evidence="ECO:0000250"
FT   SITE            4
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P25417, ECO:0000305"
SQ   SEQUENCE   98 AA;  11150 MW;  39860BB835A3F1B1 CRC64;
     MMCGAPSATQ PATAETQAIA DKVKSQLEEK ENKKFPVFKA LEFKSQLVAG KNYFIKVQVD
     EDDFVHIRVF ESLPHENKPV ALTSYQTNKG RHDELTYF