ID   CYTC_RABIT              Reviewed;         148 AA.
AC   O97862;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Cystatin-C;
DE   AltName: Full=Cystatin-3;
DE   Flags: Precursor;
GN   Name=CST3;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Japanese white; TISSUE=Bone;
RX   PubMed=9753427; DOI=10.1046/j.1365-2443.1998.00202.x;
RA   Kobori M., Ikeda Y., Nara H., Kato M., Kumegawa M., Nojima H.,
RA   Kawashima H.;
RT   "Large scale isolation of osteoclast-specific genes by an improved method
RT   involving the preparation of a subtracted cDNA library.";
RL   Genes Cells 3:459-475(1998).
CC   -!- FUNCTION: This is a thiol proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; AB009342; BAA75921.1; -; mRNA.
DR   RefSeq; NP_001076175.1; NM_001082706.1.
DR   AlphaFoldDB; O97862; -.
DR   SMR; O97862; -.
DR   STRING; 9986.ENSOCUP00000006974; -.
DR   MEROPS; I25.004; -.
DR   GeneID; 100009450; -.
DR   KEGG; ocu:100009450; -.
DR   CTD; 1471; -.
DR   eggNOG; ENOG502SC50; Eukaryota.
DR   InParanoid; O97862; -.
DR   OrthoDB; 1565344at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Reference proteome; Secreted; Signal;
KW   Thiol protease inhibitor.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..148
FT                   /note="Cystatin-C"
FT                   /id="PRO_0000006643"
FT   MOTIF           83..87
FT                   /note="Secondary area of contact"
FT   SITE            39
FT                   /note="Reactive site"
FT   DISULFID        101..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        125..145
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   148 AA;  16346 MW;  1523C831169E5B9A CRC64;
     MARSLGVPLL LLAALVVALA LAVSPAAGAR TRQSPRLLGG LEDVDAQEKD VQRALGFAES
     EYNKGSNDRY HSRALQVVRA RRQIVSGVKY YLDVLIGRTT CTKTQTNLAN CPFHDQPDLQ
     RKMLCSFEIY SVPWLNKISL LKSDCQNA