CYTIP_MOUSE
ID CYTIP_MOUSE Reviewed; 359 AA.
AC Q91VY6; A2AS77; Q3TZH1; Q8R4T4; Q9QZA9;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cytohesin-interacting protein;
DE AltName: Full=Cytohesin-binding protein HE;
DE Short=Cbp HE;
DE AltName: Full=Pleckstrin homology Sec7 and coiled-coil domains-binding protein;
GN Name=Cytip; Synonyms=Pscdbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
RX PubMed=11850456; DOI=10.1523/jneurosci.22-04-01280.2002;
RA Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y.,
RA Nakanishi S.;
RT "Tamalin, a PDZ domain-containing protein, links a protein complex
RT formation of group 1 metabotropic glutamate receptors and the guanine
RT nucleotide exchange factor cytohesins.";
RL J. Neurosci. 22:1280-1289(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-359.
RC TISSUE=Bone marrow;
RX PubMed=12909129; DOI=10.1016/s0161-5890(03)00085-3;
RA Gorski K.S., Shin T., Crafton E., Otsuji M., Rattis F.M., Huang X.,
RA Kelleher E., Francisco L., Pardoll D., Tsuchiya H.;
RT "A set of genes selectively expressed in murine dendritic cells: utility of
RT related cis-acting sequences for lentiviral gene transfer.";
RL Mol. Immunol. 40:35-47(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: By its binding to cytohesin-1 (CYTH1), it modifies activation
CC of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in
CC the cytoplasm. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CYTH1 and SNX27. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome
CC {ECO:0000250}. Note=Recruited from the cytosol to endosomes by SNX27.
CC {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK089364; BAC40855.1; -; mRNA.
DR EMBL; AK152784; BAE31493.1; -; mRNA.
DR EMBL; AK157859; BAE34237.1; -; mRNA.
DR EMBL; AK169575; BAE41236.1; -; mRNA.
DR EMBL; AK170544; BAE41869.1; -; mRNA.
DR EMBL; AK171467; BAE42473.1; -; mRNA.
DR EMBL; AK172071; BAE42810.1; -; mRNA.
DR EMBL; AL928564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007144; AAH07144.1; -; mRNA.
DR EMBL; AF374273; AAL87039.1; -; mRNA.
DR EMBL; AF192525; AAF04842.1; -; mRNA.
DR CCDS; CCDS16048.1; -.
DR RefSeq; NP_631939.1; NM_139200.4.
DR RefSeq; XP_006498075.1; XM_006498012.3.
DR RefSeq; XP_006498076.1; XM_006498013.3.
DR AlphaFoldDB; Q91VY6; -.
DR SMR; Q91VY6; -.
DR STRING; 10090.ENSMUSP00000028175; -.
DR iPTMnet; Q91VY6; -.
DR PhosphoSitePlus; Q91VY6; -.
DR EPD; Q91VY6; -.
DR jPOST; Q91VY6; -.
DR MaxQB; Q91VY6; -.
DR PaxDb; Q91VY6; -.
DR PRIDE; Q91VY6; -.
DR ProteomicsDB; 279139; -.
DR Antibodypedia; 1992; 138 antibodies from 31 providers.
DR DNASU; 227929; -.
DR Ensembl; ENSMUST00000028175; ENSMUSP00000028175; ENSMUSG00000026832.
DR GeneID; 227929; -.
DR KEGG; mmu:227929; -.
DR UCSC; uc008jsi.1; mouse.
DR CTD; 9595; -.
DR MGI; MGI:2183535; Cytip.
DR VEuPathDB; HostDB:ENSMUSG00000026832; -.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00530000063734; -.
DR HOGENOM; CLU_058640_1_0_1; -.
DR InParanoid; Q91VY6; -.
DR OMA; WLSSMTV; -.
DR OrthoDB; 966869at2759; -.
DR PhylomeDB; Q91VY6; -.
DR TreeFam; TF316315; -.
DR BioGRID-ORCS; 227929; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Cytip; mouse.
DR PRO; PR:Q91VY6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q91VY6; protein.
DR Bgee; ENSMUSG00000026832; Expressed in peripheral lymph node and 112 other tissues.
DR Genevisible; Q91VY6; MM.
DR GO; GO:0005938; C:cell cortex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0030155; P:regulation of cell adhesion; ISO:MGI.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Endosome; Reference proteome.
FT CHAIN 1..359
FT /note="Cytohesin-interacting protein"
FT /id="PRO_0000097062"
FT DOMAIN 77..166
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 166..188
FT /note="Interaction with CYTH1"
FT /evidence="ECO:0000250"
FT COILED 165..188
FT /evidence="ECO:0000255"
FT CONFLICT 6
FT /note="F -> Q (in Ref. 5; AAF04842)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 40143 MW; 4C922BC8B96B11F7 CRC64;
MSLQRFLQRQ GSNGNLEYCA DSAYGSYSVL TGQLTMEDNR RIQVLADTVA TLPRGRKQLA
LARSSSLGDF SWSQRKVVTV EKQDNGTFGF EIQTYRLQNQ NICSSEVCTM ICKVQEDSPA
HCAGLQVGDI FANVNGVSTE GFTHKQVVDL IRSSGNLLTI ETLNGTMIHR RAELEAKLQT
LKQTLKKKWV ELRSLHLQEQ RLLHGDTANS PNLENMDLDE SSLFGNLLGP SPALLDRHRL
SSESSCKSWL SSLTVDSEDG YRSSMSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR
RNRSISVTSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR AVEEEESRF
