ID   CYTIP_RAT               Reviewed;         359 AA.
AC   Q5I0L6;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cytohesin-interacting protein;
DE   AltName: Full=Pleckstrin homology Sec7 and coiled-coil domain-binding protein;
GN   Name=Cytip; Synonyms=Pscdbp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: By its binding to cytohesin-1 (CYTH1), it modifies activation
CC       of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in
CC       the cytoplasm. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CYTH1 and SNX27. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome
CC       {ECO:0000250}. Note=Recruited from the cytosol to endosomes by SNX27.
CC       {ECO:0000250}.
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DR   EMBL; BC088207; AAH88207.1; -; mRNA.
DR   RefSeq; NP_001012086.1; NM_001012086.1.
DR   AlphaFoldDB; Q5I0L6; -.
DR   SMR; Q5I0L6; -.
DR   STRING; 10116.ENSRNOP00000006387; -.
DR   PaxDb; Q5I0L6; -.
DR   Ensembl; ENSRNOT00000006387; ENSRNOP00000006387; ENSRNOG00000004772.
DR   GeneID; 311047; -.
DR   KEGG; rno:311047; -.
DR   UCSC; RGD:1307990; rat.
DR   CTD; 9595; -.
DR   RGD; 1307990; Cytip.
DR   eggNOG; KOG3528; Eukaryota.
DR   GeneTree; ENSGT00530000063734; -.
DR   HOGENOM; CLU_058640_1_0_1; -.
DR   InParanoid; Q5I0L6; -.
DR   OMA; WLSSMTV; -.
DR   OrthoDB; 966869at2759; -.
DR   PhylomeDB; Q5I0L6; -.
DR   TreeFam; TF316315; -.
DR   PRO; PR:Q5I0L6; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004772; Expressed in thymus and 18 other tissues.
DR   Genevisible; Q5I0L6; RN.
DR   GO; GO:0005938; C:cell cortex; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; ISO:RGD.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Reference proteome.
FT   CHAIN           1..359
FT                   /note="Cytohesin-interacting protein"
FT                   /id="PRO_0000097063"
FT   DOMAIN          77..166
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          166..188
FT                   /note="Interaction with CYTH1"
FT                   /evidence="ECO:0000250"
FT   COILED          165..188
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   359 AA;  39957 MW;  5704B0AA9C8C3A88 CRC64;
     MSLQRLLQQQ SSNGNLEYCA DSAYSSYPTL TGPLTVEDNR RIQMLADTVA TLPRGRKQLA
     LARSSSLGDF SCSQRKVVTV EKQDNGTFGF EIQTYRLQNQ NICSSEVCTM ICKVQEDSPA
     HCAGLQVGDI FANVNGVSTE GFTHKQVVDL IRSSGNLLTI ETLNGTMIHR RAELEAKLQT
     LKQTLKKKWV ELRSLHLQEQ RLLHGDAANS PNLENMNLDE SSLFGNLLGP SPAFLDRPRL
     SSESSCKSWL SSLTVDSEDD YGTSVSEDSI RGAFSRQTST DDECFHSKDG DEILRNASSR
     RNRSISITSS GSFSPLWESN YSSVFGTLPR KSRRGSVRKQ ILKFIPGLHR AVEEEESRF