ID   CYTI_VIGUN              Reviewed;          97 AA.
AC   Q06445;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Cysteine proteinase inhibitor;
DE   AltName: Full=Cystatin;
OS   Vigna unguiculata (Cowpea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX   NCBI_TaxID=3917;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8219051; DOI=10.1007/bf00021433;
RA   Fernandes K.V., Sabelli P.A., Barrat D.H., Richardson M., Xavier-Filho J.,
RA   Shewry P.R.;
RT   "The resistance of cowpea seeds to bruchid beetles is not related to levels
RT   of cysteine proteinase inhibitors.";
RL   Plant Mol. Biol. 23:215-219(1993).
CC   -!- SIMILARITY: Belongs to the cystatin family. Phytocystatin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z21954; CAA79954.1; -; mRNA.
DR   PIR; S39506; S39506.
DR   PDB; 4TX4; X-ray; 1.95 A; A/B=15-97.
DR   PDBsum; 4TX4; -.
DR   AlphaFoldDB; Q06445; -.
DR   SMR; Q06445; -.
DR   MEROPS; I25.014; -.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR027214; Cystatin.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   PANTHER; PTHR11413; PTHR11413; 1.
DR   Pfam; PF16845; SQAPI; 1.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Protease inhibitor; Thiol protease inhibitor.
FT   CHAIN           1..97
FT                   /note="Cysteine proteinase inhibitor"
FT                   /id="PRO_0000207161"
FT   MOTIF           49..53
FT                   /note="Secondary area of contact"
FT   SITE            5
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   HELIX           17..34
FT                   /evidence="ECO:0007829|PDB:4TX4"
FT   STRAND          39..50
FT                   /evidence="ECO:0007829|PDB:4TX4"
FT   STRAND          53..64
FT                   /evidence="ECO:0007829|PDB:4TX4"
FT   STRAND          67..78
FT                   /evidence="ECO:0007829|PDB:4TX4"
FT   HELIX           79..81
FT                   /evidence="ECO:0007829|PDB:4TX4"
FT   STRAND          83..93
FT                   /evidence="ECO:0007829|PDB:4TX4"
SQ   SEQUENCE   97 AA;  10758 MW;  0D08795E734845D5 CRC64;
     MAALGGNRDV AGNQNSLEID SLARFAVEEH NKKQNALLEF GRVVSAQQQV VSGTLYTITL
     EAKDGGQKKV YEAKVWEKPW LNFKELQEFK HVGDAPA