CYTL1_HUMAN
ID CYTL1_HUMAN Reviewed; 136 AA.
AC Q9NRR1;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Cytokine-like protein 1;
DE AltName: Full=Protein C17;
DE Flags: Precursor;
GN Name=CYTL1; Synonyms=C4orf4; ORFNames=UNQ1942/PRO4425;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Blood;
RX PubMed=10857752; DOI=10.1006/geno.2000.6170;
RA Liu X., Rapp N., Deans R., Cheng L.;
RT "Molecular cloning and chromosomal mapping of a candidate cytokine gene
RT selectively expressed in human CD34+ cells.";
RL Genomics 65:283-292(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 23-37.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10857752}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in CD34+ hematopoietic
CC cells. {ECO:0000269|PubMed:10857752}.
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DR EMBL; AF193766; AAF73372.1; -; mRNA.
DR EMBL; AY359101; AAQ89459.1; -; mRNA.
DR EMBL; BC031391; AAH31391.1; -; mRNA.
DR CCDS; CCDS3379.1; -.
DR RefSeq; NP_061129.1; NM_018659.2.
DR AlphaFoldDB; Q9NRR1; -.
DR STRING; 9606.ENSP00000303550; -.
DR iPTMnet; Q9NRR1; -.
DR PhosphoSitePlus; Q9NRR1; -.
DR BioMuta; CYTL1; -.
DR EPD; Q9NRR1; -.
DR MassIVE; Q9NRR1; -.
DR PaxDb; Q9NRR1; -.
DR PeptideAtlas; Q9NRR1; -.
DR PRIDE; Q9NRR1; -.
DR ProteomicsDB; 82406; -.
DR Antibodypedia; 22593; 104 antibodies from 21 providers.
DR DNASU; 54360; -.
DR Ensembl; ENST00000307746.9; ENSP00000303550.4; ENSG00000170891.11.
DR GeneID; 54360; -.
DR KEGG; hsa:54360; -.
DR MANE-Select; ENST00000307746.9; ENSP00000303550.4; NM_018659.3; NP_061129.1.
DR UCSC; uc003gig.5; human.
DR CTD; 54360; -.
DR DisGeNET; 54360; -.
DR GeneCards; CYTL1; -.
DR HGNC; HGNC:24435; CYTL1.
DR HPA; ENSG00000170891; Tissue enhanced (placenta).
DR MIM; 607930; gene.
DR neXtProt; NX_Q9NRR1; -.
DR OpenTargets; ENSG00000170891; -.
DR PharmGKB; PA134978681; -.
DR VEuPathDB; HostDB:ENSG00000170891; -.
DR eggNOG; ENOG502S2F0; Eukaryota.
DR GeneTree; ENSGT00390000016221; -.
DR HOGENOM; CLU_138622_1_0_1; -.
DR InParanoid; Q9NRR1; -.
DR OMA; CYSRMLT; -.
DR OrthoDB; 1466674at2759; -.
DR PhylomeDB; Q9NRR1; -.
DR TreeFam; TF333406; -.
DR PathwayCommons; Q9NRR1; -.
DR SignaLink; Q9NRR1; -.
DR BioGRID-ORCS; 54360; 12 hits in 1063 CRISPR screens.
DR ChiTaRS; CYTL1; human.
DR GenomeRNAi; 54360; -.
DR Pharos; Q9NRR1; Tbio.
DR PRO; PR:Q9NRR1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9NRR1; protein.
DR Bgee; ENSG00000170891; Expressed in tibia and 111 other tissues.
DR ExpressionAtlas; Q9NRR1; baseline and differential.
DR Genevisible; Q9NRR1; HS.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:1990079; P:cartilage homeostasis; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0050650; P:chondroitin sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR029253; CYTL1.
DR PANTHER; PTHR15974; PTHR15974; 1.
DR Pfam; PF15153; CYTL1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 23..136
FT /note="Cytokine-like protein 1"
FT /id="PRO_0000020838"
FT VARIANT 51
FT /note="S -> L (in dbSNP:rs35755546)"
FT /id="VAR_050940"
FT VARIANT 136
FT /note="R -> C (in dbSNP:rs11722554)"
FT /id="VAR_050941"
SQ SEQUENCE 136 AA; 15577 MW; 1CAEE1BFC31A3AE3 CRC64;
MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP SEPCVRYLPR
LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY TIMNSFCRRD LVFLLDDCNA
LEYPIPVTTV LPDRQR
