ID   CYTM1_HUMAN             Reviewed;          97 AA.
AC   Q9H1C7; Q8TBA5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Cysteine-rich and transmembrane domain-containing protein 1;
GN   Name=CYSTM1; Synonyms=C5orf32; ORFNames=ORF1-FL49;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skeletal muscle;
RA   Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.;
RT   "Full length sequencing of some human and murine muscular transcripts
RT   (Telethon Italy project B41).";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-90.
RC   TISSUE=Brain, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q9H1C7; O95817: BAG3; NbExp=3; IntAct=EBI-12867082, EBI-747185;
CC       Q9H1C7; Q17RD7: SYT16; NbExp=3; IntAct=EBI-12867082, EBI-10238936;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ245877; CAC21572.1; -; mRNA.
DR   EMBL; BC013643; AAH13643.1; -; mRNA.
DR   EMBL; BC023982; AAH23982.1; -; mRNA.
DR   CCDS; CCDS4221.1; -.
DR   RefSeq; NP_115788.1; NM_032412.3.
DR   AlphaFoldDB; Q9H1C7; -.
DR   BioGRID; 124070; 23.
DR   IntAct; Q9H1C7; 5.
DR   STRING; 9606.ENSP00000261811; -.
DR   iPTMnet; Q9H1C7; -.
DR   PhosphoSitePlus; Q9H1C7; -.
DR   SwissPalm; Q9H1C7; -.
DR   BioMuta; CYSTM1; -.
DR   EPD; Q9H1C7; -.
DR   jPOST; Q9H1C7; -.
DR   MassIVE; Q9H1C7; -.
DR   MaxQB; Q9H1C7; -.
DR   PaxDb; Q9H1C7; -.
DR   PeptideAtlas; Q9H1C7; -.
DR   PRIDE; Q9H1C7; -.
DR   ProteomicsDB; 80399; -.
DR   Antibodypedia; 26841; 16 antibodies from 10 providers.
DR   DNASU; 84418; -.
DR   Ensembl; ENST00000261811.6; ENSP00000261811.4; ENSG00000120306.11.
DR   GeneID; 84418; -.
DR   KEGG; hsa:84418; -.
DR   MANE-Select; ENST00000261811.6; ENSP00000261811.4; NM_032412.4; NP_115788.1.
DR   UCSC; uc003lfd.4; human.
DR   CTD; 84418; -.
DR   DisGeNET; 84418; -.
DR   GeneCards; CYSTM1; -.
DR   HGNC; HGNC:30239; CYSTM1.
DR   HPA; ENSG00000120306; Tissue enhanced (stomach).
DR   neXtProt; NX_Q9H1C7; -.
DR   OpenTargets; ENSG00000120306; -.
DR   PharmGKB; PA162380028; -.
DR   VEuPathDB; HostDB:ENSG00000120306; -.
DR   eggNOG; ENOG502S7AZ; Eukaryota.
DR   GeneTree; ENSGT00500000045016; -.
DR   HOGENOM; CLU_155323_0_0_1; -.
DR   InParanoid; Q9H1C7; -.
DR   TreeFam; TF332352; -.
DR   PathwayCommons; Q9H1C7; -.
DR   Reactome; R-HSA-6798695; Neutrophil degranulation.
DR   SignaLink; Q9H1C7; -.
DR   BioGRID-ORCS; 84418; 9 hits in 1070 CRISPR screens.
DR   ChiTaRS; CYSTM1; human.
DR   GenomeRNAi; 84418; -.
DR   Pharos; Q9H1C7; Tdark.
DR   PRO; PR:Q9H1C7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9H1C7; protein.
DR   Bgee; ENSG00000120306; Expressed in pylorus and 182 other tissues.
DR   ExpressionAtlas; Q9H1C7; baseline and differential.
DR   Genevisible; Q9H1C7; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR   InterPro; IPR043240; CYSTM1.
DR   InterPro; IPR028144; CYSTM_dom.
DR   PANTHER; PTHR47564; PTHR47564; 1.
DR   Pfam; PF12734; CYSTM; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..97
FT                   /note="Cysteine-rich and transmembrane domain-containing
FT                   protein 1"
FT                   /id="PRO_0000296358"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..43
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         90
FT                   /note="C -> S (in dbSNP:rs17852164)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034629"
SQ   SEQUENCE   97 AA;  10631 MW;  93A64A2482B41F5B CRC64;
     MNQENPPPYP GPGPTAPYPP YPPQPMGPGP MGGPYPPPQG YPYQGYPQYG WQGGPQEPPK
     TTVYVVEDQR RDELGPSTCL TACWTALCCC CLWDMLT