CYTM1_MOUSE
ID CYTM1_MOUSE Reviewed; 104 AA.
AC Q8K353; Q8BMU1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Cysteine-rich and transmembrane domain-containing protein 1;
GN Name=Cystm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR EMBL; AK028217; BAC25820.1; -; mRNA.
DR EMBL; AK167679; BAE39728.1; -; mRNA.
DR EMBL; BC028765; AAH28765.1; -; mRNA.
DR CCDS; CCDS89221.1; -.
DR AlphaFoldDB; Q8K353; -.
DR PhosphoSitePlus; Q8K353; -.
DR jPOST; Q8K353; -.
DR MaxQB; Q8K353; -.
DR PRIDE; Q8K353; -.
DR ProteomicsDB; 277941; -.
DR Antibodypedia; 26841; 16 antibodies from 10 providers.
DR Ensembl; ENSMUST00000050584; ENSMUSP00000051708; ENSMUSG00000046727.
DR Ensembl; ENSMUST00000235403; ENSMUSP00000157550; ENSMUSG00000046727.
DR Ensembl; ENSMUST00000235864; ENSMUSP00000158380; ENSMUSG00000046727.
DR Ensembl; ENSMUST00000236374; ENSMUSP00000157423; ENSMUSG00000046727.
DR Ensembl; ENSMUST00000237375; ENSMUSP00000158042; ENSMUSG00000046727.
DR UCSC; uc008enj.1; mouse.
DR MGI; MGI:1913310; Cystm1.
DR VEuPathDB; HostDB:ENSMUSG00000046727; -.
DR GeneTree; ENSGT00500000045016; -.
DR HOGENOM; CLU_155323_0_0_1; -.
DR InParanoid; Q8K353; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR ChiTaRS; Cystm1; mouse.
DR PRO; PR:Q8K353; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8K353; protein.
DR Bgee; ENSMUSG00000046727; Expressed in pyloric antrum and 250 other tissues.
DR ExpressionAtlas; Q8K353; baseline and differential.
DR Genevisible; Q8K353; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR043240; CYSTM1.
DR InterPro; IPR028144; CYSTM_dom.
DR PANTHER; PTHR47564; PTHR47564; 1.
DR Pfam; PF12734; CYSTM; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..104
FT /note="Cysteine-rich and transmembrane domain-containing
FT protein 1"
FT /id="PRO_0000296359"
FT TRANSMEM 81..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 39
FT /note="G -> R (in Ref. 1; BAC25820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 104 AA; 11402 MW; A53B91320E342D54 CRC64;
MNPENPPPYP GPGPTAPYPP YPQQPMGPMG PMGAPPPQGY PYPPPQGYPY QGYPQYGWQG
GPQEPPKTTV YVVEDQRRDD LGPSTCLTAC WTALCCCCLW DMLT
