ID   CYTR_SHIFL              Reviewed;         341 AA.
AC   P0ACP0; P06964;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=HTH-type transcriptional repressor CytR;
GN   Name=cytR; OrderedLocusNames=SF4012, S3735;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: This protein negatively controls the transcription initiation
CC       of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes
CC       and nupC, nupG, and tsx encoding transporting and pore-forming
CC       proteins. Binds cytidine and adenosine as effectors (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AE005674; AAN45445.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18755.1; -; Genomic_DNA.
DR   RefSeq; NP_709738.2; NC_004337.2.
DR   RefSeq; WP_000644904.1; NZ_UIQL01000019.1.
DR   AlphaFoldDB; P0ACP0; -.
DR   BMRB; P0ACP0; -.
DR   SMR; P0ACP0; -.
DR   STRING; 198214.SF4012; -.
DR   EnsemblBacteria; AAN45445; AAN45445; SF4012.
DR   EnsemblBacteria; AAP18755; AAP18755; S3735.
DR   GeneID; 1024402; -.
DR   GeneID; 66672158; -.
DR   KEGG; sfl:SF4012; -.
DR   KEGG; sfx:S3735; -.
DR   PATRIC; fig|198214.7.peg.4727; -.
DR   HOGENOM; CLU_037628_6_0_6; -.
DR   OMA; HSEFVFM; -.
DR   OrthoDB; 664909at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="HTH-type transcriptional repressor CytR"
FT                   /id="PRO_0000107941"
FT   DOMAIN          10..64
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        12..31
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   341 AA;  37820 MW;  0C29D8829AE7062C CRC64;
     MKAKKQETAA TMKDVALKAK VSTATVSRAL MNPDKVSQAT RNRVEKAARE VGYLPQPMGR
     NVKRNESRTI LVIVPDICDP FFSEIIRGIE VTAANHGYLV LIGDCAHQNQ QEKTFIDLII
     TKQIDGMLLL GSRLPFDASI EEQRNLPPMV MANEFAPELE LPTVHIDNLT AAFDAVNYLY
     EQGHKRIGCI AGPEEMPLCH YRLQGYVQAL RRCGIMVDPQ YIARGDFTFE AGSKAMQQLL
     DLPQPPTAVF CHSDVMALGA LSQAKRQGLK VPEDLSIIGF DNIDLTQFCD PPLTTIAQPR
     YEIGREAMLL LLDQMQGQHV GSGSRLMDCE LIIRGSTRAL P