ID   CYTX_BOVIN              Reviewed;         101 AA.
AC   P35478;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Stefin-C;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
RC   TISSUE=Thymus;
RX   PubMed=8463267; DOI=10.1016/s0021-9258(18)53178-1;
RA   Turk B., Krizaj I., Kralj B., Dolenc I., Popovic T., Bieth J.G., Turk V.;
RT   "Bovine stefin C, a new member of the stefin family.";
RL   J. Biol. Chem. 268:7323-7329(1993).
CC   -!- FUNCTION: Strong inhibitor of papain and cathepsin L but poor inhibitor
CC       of cathepsin B.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   PIR; A46083; A46083.
DR   AlphaFoldDB; P35478; -.
DR   SMR; P35478; -.
DR   STRING; 9913.ENSBTAP00000024208; -.
DR   MEROPS; I25.003; -.
DR   iPTMnet; P35478; -.
DR   PaxDb; P35478; -.
DR   PeptideAtlas; P35478; -.
DR   PRIDE; P35478; -.
DR   eggNOG; ENOG502SF2X; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW   Reference proteome; Thiol protease inhibitor.
FT   CHAIN           1..101
FT                   /note="Stefin-C"
FT                   /id="PRO_0000207145"
FT   MOTIF           49..53
FT                   /note="Secondary area of contact"
FT   SITE            7
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000269|PubMed:8463267"
SQ   SEQUENCE   101 AA;  11603 MW;  E76004BFBA23F5C3 CRC64;
     MWGPNLGGFS DTQDATAEIQ AIADQVKSQL EEKENKKFPV FKAVKFRSQV VAGMNYLIKV
     QVDEDDFVHI RVFESLPHEN KPVALTSYQT NKVRHDELTY F