ID   CYT_ONCMY               Reviewed;         130 AA.
AC   Q91195;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Cystatin;
DE   Flags: Precursor;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Li F., An H., Seymour T.A., Morrissey M.T., Barnes D.W.;
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cysteine proteinase inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; U33555; AAA82049.1; -; mRNA.
DR   RefSeq; NP_001118176.1; NM_001124704.1.
DR   AlphaFoldDB; Q91195; -.
DR   SMR; Q91195; -.
DR   MEROPS; I25.041; -.
DR   GeneID; 100136752; -.
DR   KEGG; omy:100136752; -.
DR   OrthoDB; 1565344at2759; -.
DR   SABIO-RK; Q91195; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IDA:AgBase.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Secreted; Signal;
KW   Thiol protease inhibitor.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..130
FT                   /note="Cystatin"
FT                   /id="PRO_0000006666"
FT   MOTIF           67..71
FT                   /note="Secondary area of contact"
FT                   /evidence="ECO:0000250"
FT   SITE            23
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..128
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14600 MW;  23CD7AB960BAFAC4 CRC64;
     MEWKIVVPLF AVAFTVANAG LIGGPMDANM NDQGTRDALQ FAVVEHNKKT NDMFVRQVAK
     VVNAQKQVVS GMKYIFTVQM GRTPCRKGGV EKVCSVHKDP QMAVPYKCTF EVWSRPWMSD
     IQMVKNQCES