ID   CYT_POGBA               Reviewed;         144 AA.
AC   Q2XXN5;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Cystatin-POGU1;
DE   Flags: Precursor;
OS   Pogona barbata (Bearded dragon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Acrodonta; Agamidae; Amphibolurinae; Pogona.
OX   NCBI_TaxID=52202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Inhibits various C1 cysteine proteases including cathepsin L,
CC       papain and cathepsin B. This protein has no toxic activity and its
CC       function in the venom is unknown. It may play a role as a housekeeping
CC       or regulatory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   EMBL; DQ139910; AAZ75616.1; -; mRNA.
DR   AlphaFoldDB; Q2XXN5; -.
DR   SMR; Q2XXN5; -.
DR   MEROPS; I25.012; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Secreted; Signal;
KW   Thiol protease inhibitor.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..144
FT                   /note="Cystatin-POGU1"
FT                   /id="PRO_0000423040"
FT   DOMAIN          29..128
FT                   /note="Cystatin"
FT   MOTIF           73..77
FT                   /note="Secondary area of contact"
FT                   /evidence="ECO:0000250"
FT   SITE            29
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   DISULFID        91..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        119..139
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   144 AA;  15633 MW;  2D2008D5C74A99B6 CRC64;
     MASGGSPVWA LVALLSLLPL VARGERAVGA PEEVPVSNPG VQEAARFALE AYNRASNSMF
     CYKPVRVLKA ETQVVSGMQY YLTVEIVNTR CEKKVGCGLK NMGSENCAVP SEAEQKQICE
     FVVWSRPWMQ DTRLSSISCT PSSS