CYYR1_HUMAN
ID CYYR1_HUMAN Reviewed; 154 AA.
AC Q96J86; A0A059TD09; A8MTU9; B2R845; Q53ER3; Q5JPD0; Q96NV7; R9QAJ4; W8CQB3;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Cysteine and tyrosine-rich protein 1;
DE AltName: Full=Proline-rich domain-containing protein;
DE Flags: Precursor;
GN Name=CYYR1; Synonyms=C21orf95;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12062809; DOI=10.1016/s0378-1119(02)00550-4;
RA Vitale L., Casadei R., Canaider S., Lenzi L., Strippoli P., D'Addabbo P.,
RA Giannone S., Carinci P., Zannotti M.;
RT "Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human
RT chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and
RT defines a new family of highly conserved vertebrate-specific genes.";
RL Gene 290:141-151(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL Genomics 79:824-832(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5 AND 6).
RC TISSUE=Brain;
RA Casadei R., Pelleri M.C., Vitale L., Facchin F., Canaider S., Strippoli P.,
RA Vian M., Piovesan A., Bianconi E., Mariani E., Piva F., Frabetti F.;
RT "Characterization of human gene locus CYYR1: a complex multi-transcript
RT system.";
RL Mol. Biol. Rep. 0:0-0(2014).
RN [9]
RP VARIANT SER-111, ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RX PubMed=17442112; DOI=10.1186/1471-2407-7-66;
RA Vitale L., Frabetti F., Huntsman S.A., Canaider S., Casadei R., Lenzi L.,
RA Facchin F., Carinci P., Zannotti M., Coppola D., Strippoli P.;
RT "Sequence, 'subtle' alternative splicing and expression of the CYYR1
RT (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors.";
RL BMC Cancer 7:66-66(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96J86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96J86-2; Sequence=VSP_034245;
CC Name=3;
CC IsoId=Q96J86-3; Sequence=VSP_057148, VSP_057150;
CC Name=4;
CC IsoId=Q96J86-4; Sequence=VSP_057143, VSP_057149;
CC Name=5;
CC IsoId=Q96J86-5; Sequence=VSP_057144, VSP_057147;
CC Name=6;
CC IsoId=Q96J86-6; Sequence=VSP_057145, VSP_057146;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12036297,
CC ECO:0000269|PubMed:17442112}.
CC -!- SIMILARITY: Belongs to the CYYR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB70764.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF401639; AAK84158.1; -; mRNA.
DR EMBL; AY061853; AAL35737.1; -; mRNA.
DR EMBL; AK054581; BAB70764.1; ALT_INIT; mRNA.
DR EMBL; AK313231; BAG36042.1; -; mRNA.
DR EMBL; AK223576; BAD97296.1; -; mRNA.
DR EMBL; AL833200; CAI46188.1; -; mRNA.
DR EMBL; JF693912; AFC01211.1; -; mRNA.
DR EMBL; JF693913; AFC01212.1; -; mRNA.
DR EMBL; KC843341; AGM21753.1; -; mRNA.
DR EMBL; KF154022; AHY03237.1; -; mRNA.
DR EMBL; AP001596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036761; AAH36761.1; -; mRNA.
DR RefSeq; NP_001307697.1; NM_001320768.1. [Q96J86-2]
DR RefSeq; NP_443186.2; NM_052954.3. [Q96J86-1]
DR AlphaFoldDB; Q96J86; -.
DR BioGRID; 125484; 7.
DR IntAct; Q96J86; 4.
DR STRING; 9606.ENSP00000299340; -.
DR PhosphoSitePlus; Q96J86; -.
DR BioMuta; CYYR1; -.
DR DMDM; 27151488; -.
DR MassIVE; Q96J86; -.
DR PaxDb; Q96J86; -.
DR PeptideAtlas; Q96J86; -.
DR PRIDE; Q96J86; -.
DR ProteomicsDB; 76900; -. [Q96J86-1]
DR ProteomicsDB; 76901; -. [Q96J86-2]
DR Antibodypedia; 60029; 71 antibodies from 16 providers.
DR DNASU; 116159; -.
DR Ensembl; ENST00000299340.9; ENSP00000299340.4; ENSG00000166265.13. [Q96J86-1]
DR Ensembl; ENST00000400043.3; ENSP00000382918.3; ENSG00000166265.13. [Q96J86-3]
DR Ensembl; ENST00000652641.2; ENSP00000498505.1; ENSG00000166265.13. [Q96J86-2]
DR GeneID; 116159; -.
DR KEGG; hsa:116159; -.
DR MANE-Select; ENST00000652641.2; ENSP00000498505.1; NM_001320768.2; NP_001307697.2. [Q96J86-2]
DR UCSC; uc002ymd.4; human. [Q96J86-1]
DR CTD; 116159; -.
DR DisGeNET; 116159; -.
DR GeneCards; CYYR1; -.
DR HGNC; HGNC:16274; CYYR1.
DR HPA; ENSG00000166265; Low tissue specificity.
DR MIM; 616020; gene.
DR neXtProt; NX_Q96J86; -.
DR OpenTargets; ENSG00000166265; -.
DR PharmGKB; PA27127; -.
DR VEuPathDB; HostDB:ENSG00000166265; -.
DR eggNOG; ENOG502S121; Eukaryota.
DR GeneTree; ENSGT00500000044986; -.
DR HOGENOM; CLU_143594_0_0_1; -.
DR InParanoid; Q96J86; -.
DR OMA; YSYDYEM; -.
DR OrthoDB; 1592053at2759; -.
DR PhylomeDB; Q96J86; -.
DR TreeFam; TF332064; -.
DR PathwayCommons; Q96J86; -.
DR SignaLink; Q96J86; -.
DR BioGRID-ORCS; 116159; 14 hits in 1060 CRISPR screens.
DR ChiTaRS; CYYR1; human.
DR GeneWiki; CYYR1; -.
DR GenomeRNAi; 116159; -.
DR Pharos; Q96J86; Tbio.
DR PRO; PR:Q96J86; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q96J86; protein.
DR Bgee; ENSG00000166265; Expressed in visceral pleura and 178 other tissues.
DR Genevisible; Q96J86; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022640; CYYR1.
DR PANTHER; PTHR38490; PTHR38490; 1.
DR Pfam; PF10873; CYYR1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..154
FT /note="Cysteine and tyrosine-rich protein 1"
FT /id="PRO_0000021054"
FT TOPO_DOM 30..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 124..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 60..112
FT /note="GTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYP
FT G -> RTTTLRSRPRDGILCRLASSILPHPTGSSTAFSTPSLSWKRKEIIYLPEQNMC
FT (in isoform 4)"
FT /id="VSP_057143"
FT VAR_SEQ 60..75
FT /note="GTAIAGIVFGIVFIMG -> REFKDHQTFEENIKYE (in isoform 5)"
FT /id="VSP_057144"
FT VAR_SEQ 60..64
FT /note="GTAIA -> CCCPR (in isoform 6)"
FT /id="VSP_057145"
FT VAR_SEQ 65..154
FT /note="Missing (in isoform 6)"
FT /id="VSP_057146"
FT VAR_SEQ 76..154
FT /note="Missing (in isoform 5)"
FT /id="VSP_057147"
FT VAR_SEQ 111
FT /note="P -> PA (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_034245"
FT VAR_SEQ 112..132
FT /note="GPPPYGHDHEMEYCADLPPPY -> EYELHEAEILVYFVQHSIPSM (in
FT isoform 3)"
FT /id="VSP_057148"
FT VAR_SEQ 113..154
FT /note="Missing (in isoform 4)"
FT /id="VSP_057149"
FT VAR_SEQ 133..154
FT /note="Missing (in isoform 3)"
FT /id="VSP_057150"
FT VARIANT 95
FT /note="R -> H (in dbSNP:rs35253087)"
FT /id="VAR_044042"
FT VARIANT 111
FT /note="P -> S (in dbSNP:rs1215339708)"
FT /evidence="ECO:0000269|PubMed:17442112"
FT /id="VAR_044043"
SQ SEQUENCE 154 AA; 16626 MW; 0B0E5BD3FEC65F7D CRC64;
MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY YAYIGNILSG
TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR TTHINTVSSY PGPPPYGHDH
EMEYCADLPP PYSPTPQGPA QRSPPPPYPG NARK
